IKBKG

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

GO terms:

Biological Process:
activation of MAPK activity [GO:0000187],
stimulatory C-type lectin receptor signaling pathway [GO:0002223],
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479],
MyD88-independent toll-like receptor signaling pathway [GO:0002756],
apoptotic process [GO:0006915],
inflammatory response [GO:0006954],
immune response [GO:0006955],
cellular response to DNA damage stimulus [GO:0006974],
I-kappaB kinase/NF-kappaB signaling [GO:0007249],
JNK cascade [GO:0007254],
response to virus [GO:0009615],
regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803],
viral process [GO:0016032],
positive regulation of macroautophagy [GO:0016239],
protein deubiquitination [GO:0016579],
TRIF-dependent toll-like receptor signaling pathway [GO:0035666],
Fc-epsilon receptor signaling pathway [GO:0038095],
regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
anoikis [GO:0043276],
innate immune response [GO:0045087],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
T cell receptor signaling pathway [GO:0050852],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
stress-activated MAPK cascade [GO:0051403],
establishment of vesicle localization [GO:0051650],
macromolecular complex assembly [GO:0065003],
nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423],
interleukin-1-mediated signaling pathway [GO:0070498],
negative regulation of neuron death [GO:1901215],
B cell homeostasis [GO:0001782],
activation of NF-kappaB-inducing kinase activity [GO:0007250],
positive regulation of gene expression [GO:0010628],
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236],

Molecular Function:
protein binding [GO:0005515],
protein domain specific binding [GO:0019904],
ubiquitin protein ligase binding [GO:0031625],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
peroxisome proliferator activated receptor binding [GO:0042975],
macromolecular complex binding [GO:0044877],
metal ion binding [GO:0046872],
protein heterodimerization activity [GO:0046982],
K63-linked polyubiquitin binding [GO:0070530],
linear polyubiquitin binding [GO:1990450],
transferrin receptor binding [GO:1990459],

Cellular Component:
ubiquitin ligase complex [GO:0000151],
spindle pole [GO:0000922],
intracellular [GO:0005622],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
IkappaB kinase complex [GO:0008385],
macromolecular complex [GO:0032991],
mitotic spindle [GO:0072686],