AOX1

aldehyde oxidase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2, Li-Fraumeni Human YES
30626320 HBEC Human NO
30987592 MCF7 Breast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
32109515 Brain Mouse NO

GO terms:

Biological Process:
xanthine catabolic process [GO:0009115],
drug metabolic process [GO:0017144],
electron transport chain [GO:0022900],
vitamin B6 metabolic process [GO:0042816],
oxidation-reduction process [GO:0055114],

Molecular Function:
aldehyde oxidase activity [GO:0004031],
xanthine dehydrogenase activity [GO:0004854],
iron ion binding [GO:0005506],
electron carrier activity [GO:0009055],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
molybdopterin cofactor binding [GO:0043546],
flavin adenine dinucleotide binding [GO:0050660],
NAD binding [GO:0051287],
2 iron, 2 sulfur cluster binding [GO:0051537],
FAD binding [GO:0071949],
oxidoreductase activity [GO:0016491],
metal ion binding [GO:0046872],
retinal oxidase activity [GO:0050250],
iron-sulfur cluster binding [GO:0051536],

Cellular Component:
cytosol [GO:0005829],
extracellular exosome [GO:0070062],
cytoplasm [GO:0005737],