IFNG

interferon gamma

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
19071156 HUVEC Human NO
25982278 HeLa, MCF7, TC-1, B16 Human, Mouse NO
28791835 MSC Bone marrow Mouse NO
29796172 SK-BR-3, BT-474, MCF7, T-47D, HCC-1419, MDA-MB-231, MDA-MB-469 Human NO
30226595 B16 Mouse NO
31103748 A549 Human
31184599 WI-38 YES
31186408 OV-90,OV-1369, OV-1946 Human YES
31635416 Primary fibroblasts derived from skin Human YES
31727161 Brain Human NO
31925782 Primary NK cells derived from blood Human NO
31947966 WM115, MCF7, T24 Human NO
32075966 IMR-90 Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
microglial cell activation [GO:0001774],
positive regulation of protein phosphorylation [GO:0001934],
adaptive immune response [GO:0002250],
macrophage activation involved in immune response [GO:0002281],
apoptotic process [GO:0006915],
humoral immune response [GO:0006959],
cell cycle arrest [GO:0007050],
cell surface receptor signaling pathway [GO:0007166],
JAK-STAT cascade [GO:0007259],
positive regulation of cell proliferation [GO:0008284],
response to virus [GO:0009615],
positive regulation of autophagy [GO:0010508],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
positive regulation of epithelial cell migration [GO:0010634],
regulation of protein ADP-ribosylation [GO:0010835],
positive regulation of receptor biosynthetic process [GO:0010870],
macrophage differentiation [GO:0030225],
negative regulation of epithelial cell differentiation [GO:0030857],
positive regulation of protein complex assembly [GO:0031334],
negative regulation of interleukin-17 production [GO:0032700],
positive regulation of interleukin-12 production [GO:0032735],
positive regulation of interleukin-23 production [GO:0032747],
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [GO:0032834],
positive regulation of peptidyl-serine phosphorylation of STAT protein [GO:0033141],
positive regulation of smooth muscle cell apoptotic process [GO:0034393],
interleukin-12-mediated signaling pathway [GO:0035722],
regulation of growth [GO:0040008],
positive regulation of protein import into nucleus [GO:0042307],
positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531],
positive regulation of tumor necrosis factor biosynthetic process [GO:0042535],
positive regulation of chemokine biosynthetic process [GO:0045080],
positive regulation of MHC class II biosynthetic process [GO:0045348],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
regulation of regulatory T cell differentiation [GO:0045589],
positive regulation of osteoclast differentiation [GO:0045672],
positive regulation of glycolytic process [GO:0045821],
negative regulation of transcription, DNA-templated [GO:0045892],
astrocyte activation [GO:0048143],
negative regulation of smooth muscle cell proliferation [GO:0048662],
positive regulation of cytokine secretion [GO:0050715],
positive regulation of interleukin-1 beta biosynthetic process [GO:0050725],
positive regulation of inflammatory response [GO:0050729],
positive regulation of phagocytosis [GO:0050766],
positive regulation of neurogenesis [GO:0050769],
regulation of insulin secretion [GO:0050796],
positive regulation of membrane protein ectodomain proteolysis [GO:0051044],
positive regulation of nitrogen compound metabolic process [GO:0051173],
defense response to virus [GO:0051607],
positive regulation of killing of cells of other organism [GO:0051712],
positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770],
interferon-gamma-mediated signaling pathway [GO:0060333],
regulation of interferon-gamma-mediated signaling pathway [GO:0060334],
positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity [GO:0060550],
positive regulation of fructose 1,6-bisphosphate metabolic process [GO:0060552],
positive regulation of vitamin D biosynthetic process [GO:0060557],
positive regulation of calcidiol 1-monooxygenase activity [GO:0060559],
positive regulation of protein serine/threonine kinase activity [GO:0071902],
positive regulation of protein deacetylation [GO:0090312],
extrinsic apoptotic signaling pathway [GO:0097191],
negative regulation of beta-amyloid clearance [GO:1900222],
positive regulation of neuron death [GO:1901216],
positive regulation of cellular respiration [GO:1901857],
positive regulation of beta-amyloid formation [GO:1902004],
negative regulation of tau-protein kinase activity [GO:1902948],
positive regulation of protein localization to plasma membrane [GO:1903078],
positive regulation of exosomal secretion [GO:1903543],
positive regulation of ferrous iron import across plasma membrane [GO:1904440],
positive regulation of tumor necrosis factor secretion [GO:1904469],
positive regulation of NMDA glutamate receptor activity [GO:1904783],
positive regulation of core promoter binding [GO:1904798],
positive regulation of tumor necrosis factor (ligand) superfamily member 11 production [GO:2000309],
positive regulation of interleukin-6 secretion [GO:2000778],
neutrophil apoptotic process [GO:0001781],
regulation of the force of heart contraction [GO:0002026],
CD8-positive, alpha-beta T cell differentiation involved in immune response [GO:0002302],
regulation of transcription, DNA-templated [GO:0006355],
inflammatory cell apoptotic process [GO:0006925],
immune response [GO:0006955],
negative regulation of cell proliferation [GO:0008285],
antigen processing and presentation [GO:0019882],
neutrophil chemotaxis [GO:0030593],
endoplasmic reticulum unfolded protein response [GO:0030968],
negative regulation of myelination [GO:0031642],
positive regulation of synaptic transmission, cholinergic [GO:0032224],
positive regulation of tumor necrosis factor production [GO:0032760],
positive regulation of T cell proliferation [GO:0042102],
defense response to bacterium [GO:0042742],
defense response to protozoan [GO:0042832],
positive regulation of apoptotic process [GO:0043065],
positive regulation by host of viral process [GO:0044794],
positive regulation of interleukin-12 biosynthetic process [GO:0045084],
positive regulation of interleukin-6 biosynthetic process [GO:0045410],
positive regulation of neuron differentiation [GO:0045666],
negative regulation of osteoclast differentiation [GO:0045671],
positive regulation of cell adhesion [GO:0045785],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
negative regulation of fibroblast proliferation [GO:0048147],
positive regulation of isotype switching to IgG isotypes [GO:0048304],
regulation of defense response to virus by host [GO:0050691],
positive regulation of interleukin-1 beta secretion [GO:0050718],
regulation of immune response [GO:0050776],
T cell receptor signaling pathway [GO:0050852],
sensory perception of mechanical stimulus [GO:0050954],
regulation of glial cell proliferation [GO:0060251],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to interleukin-18 [GO:0071351],
negative regulation of glomerular mesangial cell proliferation [GO:0072125],
regulation of neuronal action potential [GO:0098908],
regulation of hepatocyte proliferation [GO:2000345],

Molecular Function:
cytokine activity [GO:0005125],
interferon-gamma receptor binding [GO:0005133],
protein binding [GO:0005515],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cytoplasm [GO:0005737],
external side of plasma membrane [GO:0009897],
neuron projection [GO:0043005],
perikaryon [GO:0043204],