IDH1

isocitrate dehydrogenase (NADP(+)) 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
24922649 Brain Human NO
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31110157 OVCAR-3, OVCAR-10 Human NO
31945125 Primary astrocytes derived from brain Human YES
31983656 MSC Human YES

GO terms:

Biological Process:
glyoxylate cycle [GO:0006097],
tricarboxylic acid cycle [GO:0006099],
isocitrate metabolic process [GO:0006102],
2-oxoglutarate metabolic process [GO:0006103],
protein targeting to peroxisome [GO:0006625],
NADP metabolic process [GO:0006739],
NADPH regeneration [GO:0006740],
glutathione metabolic process [GO:0006749],
response to oxidative stress [GO:0006979],
female gonad development [GO:0008585],
neutrophil degranulation [GO:0043312],
response to steroid hormone [GO:0048545],
regulation of phospholipid catabolic process [GO:0060696],
regulation of phospholipid biosynthetic process [GO:0071071],
response to organic cyclic compound [GO:0014070],
oxidation-reduction process [GO:0055114],

Molecular Function:
magnesium ion binding [GO:0000287],
isocitrate dehydrogenase (NADP+) activity [GO:0004450],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
cadherin binding [GO:0045296],
NADP binding [GO:0050661],
NAD binding [GO:0051287],
isocitrate dehydrogenase activity [GO:0004448],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
peroxisome [GO:0005777],
peroxisomal matrix [GO:0005782],
cytosol [GO:0005829],
secretory granule lumen [GO:0034774],
extracellular exosome [GO:0070062],
tertiary granule lumen [GO:1904724],
ficolin-1-rich granule lumen [GO:1904813],