IDE

insulin degrading enzyme

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
protein targeting to peroxisome [GO:0006625],
insulin receptor signaling pathway [GO:0008286],
determination of adult lifespan [GO:0008340],
bradykinin catabolic process [GO:0010815],
ubiquitin homeostasis [GO:0010992],
antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885],
protein catabolic process [GO:0030163],
positive regulation of protein binding [GO:0032092],
hormone catabolic process [GO:0042447],
peptide catabolic process [GO:0043171],
cellular protein catabolic process [GO:0044257],
positive regulation of protein catabolic process [GO:0045732],
negative regulation of proteolysis [GO:0045861],
viral entry into host cell [GO:0046718],
beta-amyloid metabolic process [GO:0050435],
proteolysis involved in cellular protein catabolic process [GO:0051603],
beta-amyloid clearance [GO:0097242],
insulin metabolic process [GO:1901142],
insulin catabolic process [GO:1901143],
regulation of aerobic respiration [GO:1903715],
metabolic process [GO:0008152],

Molecular Function:
beta-amyloid binding [GO:0001540],
virus receptor activity [GO:0001618],
endopeptidase activity [GO:0004175],
metalloendopeptidase activity [GO:0004222],
protein binding [GO:0005515],
ATP binding [GO:0005524],
zinc ion binding [GO:0008270],
ATPase activity [GO:0016887],
beta-endorphin binding [GO:0031626],
peptide binding [GO:0042277],
protein homodimerization activity [GO:0042803],
insulin binding [GO:0043559],
macromolecular complex binding [GO:0044877],
nucleotide binding [GO:0000166],
catalytic activity [GO:0003824],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],
peptide hormone binding [GO:0017046],
identical protein binding [GO:0042802],
metal ion binding [GO:0046872],

Cellular Component:
extracellular space [GO:0005615],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
peroxisome [GO:0005777],
peroxisomal matrix [GO:0005782],
cytosol [GO:0005829],
external side of plasma membrane [GO:0009897],
cell surface [GO:0009986],
basolateral plasma membrane [GO:0016323],
cytosolic proteasome complex [GO:0031597],
extracellular exosome [GO:0070062],
extracellular region [GO:0005576],
plasma membrane [GO:0005886],
membrane [GO:0016020],