annexin A1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES
31971661 Primary mesenchymal stem cells derived from adipose tissue Mouse YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31915373 Hheart_LA_VS healthy Smooth muscle cell Human NO

GO terms:

Biological Process:
neutrophil homeostasis [GO:0001780],
adaptive immune response [GO:0002250],
monocyte chemotaxis [GO:0002548],
regulation of leukocyte migration [GO:0002685],
phagocytosis [GO:0006909],
inflammatory response [GO:0006954],
signal transduction [GO:0007165],
cell surface receptor signaling pathway [GO:0007166],
G-protein coupled receptor signaling pathway [GO:0007186],
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187],
regulation of cell shape [GO:0008360],
response to X-ray [GO:0010165],
myoblast migration involved in skeletal muscle regeneration [GO:0014839],
peptide cross-linking [GO:0018149],
cytokine-mediated signaling pathway [GO:0019221],
insulin secretion [GO:0030073],
keratinocyte differentiation [GO:0030216],
prostate gland development [GO:0030850],
endocrine pancreas development [GO:0031018],
positive regulation of vesicle fusion [GO:0031340],
positive regulation of prostaglandin biosynthetic process [GO:0031394],
actin cytoskeleton reorganization [GO:0031532],
response to estradiol [GO:0032355],
DNA duplex unwinding [GO:0032508],
regulation of interleukin-1 production [GO:0032652],
positive regulation of interleukin-2 production [GO:0032743],
positive regulation of neutrophil apoptotic process [GO:0033031],
cellular response to vascular endothelial growth factor stimulus [GO:0035924],
gliogenesis [GO:0042063],
positive regulation of T cell proliferation [GO:0042102],
regulation of cell proliferation [GO:0042127],
response to drug [GO:0042493],
negative regulation of apoptotic process [GO:0043066],
response to peptide hormone [GO:0043434],
estrous cycle [GO:0044849],
innate immune response [GO:0045087],
positive regulation of T-helper 1 cell differentiation [GO:0045627],
negative regulation of T-helper 2 cell differentiation [GO:0045629],
negative regulation of exocytosis [GO:0045920],
alpha-beta T cell differentiation [GO:0046632],
regulation of hormone secretion [GO:0046883],
arachidonic acid secretion [GO:0050482],
regulation of inflammatory response [GO:0050727],
cellular response to hydrogen peroxide [GO:0070301],
hepatocyte differentiation [GO:0070365],
prolactin secretion [GO:0070459],
response to interleukin-1 [GO:0070555],
cellular response to glucocorticoid stimulus [GO:0071385],
granulocyte chemotaxis [GO:0071621],
positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050],
positive regulation of wound healing [GO:0090303],
neutrophil clearance [GO:0097350],
cell-cell adhesion [GO:0098609],
positive regulation of G1/S transition of mitotic cell cycle [GO:1900087],
negative regulation of phospholipase A2 activity [GO:1900138],
negative regulation of interleukin-8 secretion [GO:2000483],
immune system process [GO:0002376],
positive regulation of apoptotic process [GO:0043065],
negative regulation of protein secretion [GO:0050709],

Molecular Function:
single-stranded DNA binding [GO:0003697],
single-stranded RNA binding [GO:0003727],
receptor binding [GO:0005102],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
phospholipid binding [GO:0005543],
calcium-dependent phospholipid binding [GO:0005544],
phospholipase A2 inhibitor activity [GO:0019834],
double-stranded DNA-dependent ATP-dependent DNA helicase activity [GO:0036121],
identical protein binding [GO:0042802],
calcium-dependent protein binding [GO:0048306],
cadherin binding involved in cell-cell adhesion [GO:0098641],
DNA/DNA annealing activity [GO:1990814],
phospholipase inhibitor activity [GO:0004859],
metal ion binding [GO:0046872],

Cellular Component:
cornified envelope [GO:0001533],
phagocytic cup [GO:0001891],
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
endosome [GO:0005768],
cytosol [GO:0005829],
actin filament [GO:0005884],
plasma membrane [GO:0005886],
adherens junction [GO:0005912],
focal adhesion [GO:0005925],
cell surface [GO:0009986],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
lateral plasma membrane [GO:0016328],
extrinsic component of membrane [GO:0019898],
cytoplasmic vesicle membrane [GO:0030659],
extrinsic component of external side of plasma membrane [GO:0031232],
extrinsic component of endosome membrane [GO:0031313],
motile cilium [GO:0031514],
early endosome membrane [GO:0031901],
mitochondrial membrane [GO:0031966],
vesicle [GO:0031982],
macromolecular complex [GO:0032991],
sarcolemma [GO:0042383],
mast cell granule [GO:0042629],
extracellular exosome [GO:0070062],
synaptic membrane [GO:0097060],
cilium [GO:0005929],
membrane [GO:0016020],
cytoplasmic vesicle [GO:0031410],
cell projection [GO:0042995],