HSPB1

heat shock protein family B (small) member 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
30790400 Primary endothelial cells derived from lung Mouse NO
31945125 Primary astrocytes derived from brain Human YES
31964978 Primary astrocytes derived from brain Mouse YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
18089808 MCF 1A, MCF7, DU 145, HCT 116 Human NO
31945054 IMR-90 Human YES

GO terms:

Biological Process:
retina homeostasis [GO:0001895],
regulation of protein phosphorylation [GO:0001932],
regulation of translational initiation [GO:0006446],
negative regulation of protein kinase activity [GO:0006469],
response to unfolded protein [GO:0006986],
response to virus [GO:0009615],
regulation of autophagy [GO:0010506],
viral process [GO:0016032],
positive regulation of interleukin-1 beta production [GO:0032731],
intracellular signal transduction [GO:0035556],
cellular response to vascular endothelial growth factor stimulus [GO:0035924],
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033],
positive regulation of tumor necrosis factor biosynthetic process [GO:0042535],
negative regulation of apoptotic process [GO:0043066],
regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122],
regulation of mRNA stability [GO:0043488],
positive regulation of blood vessel endothelial cell migration [GO:0043536],
positive regulation of angiogenesis [GO:0045766],
chaperone-mediated protein folding [GO:0061077],
platelet aggregation [GO:0070527],
negative regulation of protein serine/threonine kinase activity [GO:0071901],
anterograde axonal protein transport [GO:0099641],
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176],
positive regulation of endothelial cell chemotaxis [GO:2001028],
positive regulation of neuron projection development [GO:0010976],
negative regulation of oxidative stress-induced cell death [GO:1903202],
negative regulation of apoptotic signaling pathway [GO:2001234],

Molecular Function:
RNA binding [GO:0003723],
protein kinase C binding [GO:0005080],
protein binding [GO:0005515],
protein kinase C inhibitor activity [GO:0008426],
protein kinase binding [GO:0019901],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
ubiquitin binding [GO:0043130],
protein binding involved in protein folding [GO:0044183],

Cellular Component:
proteasome complex [GO:0000502],
extracellular space [GO:0005615],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
spindle [GO:0005819],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
Z disc [GO:0030018],
extracellular exosome [GO:0070062],
axon cytoplasm [GO:1904115],
intracellular [GO:0005622],
axon [GO:0030424],
dendrite [GO:0030425],
M band [GO:0031430],
I band [GO:0031674],
perikaryon [GO:0043204],
contractile fiber [GO:0043292],
synapse [GO:0045202],
cardiac myofibril [GO:0097512],
postsynaptic density membrane [GO:0098839],