HSPA8

heat shock protein family A (Hsp70) member 8

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945054 IMR-90 Human YES

GO terms:

Biological Process:
mRNA splicing, via spliceosome [GO:0000398],
protein folding [GO:0006457],
response to unfolded protein [GO:0006986],
neurotransmitter secretion [GO:0007269],
axo-dendritic transport [GO:0008088],
cellular response to starvation [GO:0009267],
viral process [GO:0016032],
vesicle-mediated transport [GO:0016192],
cytokine-mediated signaling pathway [GO:0019221],
regulation of protein stability [GO:0031647],
cellular response to unfolded protein [GO:0034620],
protein refolding [GO:0042026],
regulation of protein complex assembly [GO:0043254],
neutrophil degranulation [GO:0043312],
regulation of mRNA stability [GO:0043488],
positive regulation by host of viral genome replication [GO:0044829],
negative regulation of transcription, DNA-templated [GO:0045892],
ATP metabolic process [GO:0046034],
positive regulation of mRNA splicing, via spliceosome [GO:0048026],
chaperone mediated protein folding requiring cofactor [GO:0051085],
regulation of cell cycle [GO:0051726],
membrane organization [GO:0061024],
regulation of protein complex stability [GO:0061635],
chaperone-mediated autophagy [GO:0061684],
late endosomal microautophagy [GO:0061738],
protein targeting to lysosome involved in chaperone-mediated autophagy [GO:0061740],
chaperone-mediated protein transport involved in chaperone-mediated autophagy [GO:0061741],
clathrin coat disassembly [GO:0072318],
regulation of cellular response to heat [GO:1900034],
negative regulation of fibril organization [GO:1902904],
regulation of protein import [GO:1904589],
chaperone-mediated autophagy translocation complex disassembly [GO:1904764],
slow axonal transport [GO:1990832],
positive regulation of T cell mediated cytotoxicity [GO:0001916],
mRNA processing [GO:0006397],
protein import into nucleus [GO:0006606],
RNA splicing [GO:0008380],
positive regulation of gene expression [GO:0010628],
negative regulation of cardiac muscle cell apoptotic process [GO:0010667],
positive regulation of catalytic activity [GO:0043085],
cellular protein complex disassembly [GO:0043624],
modulation by host of viral process [GO:0044788],
positive regulation of proteolysis [GO:0045862],
protein autophosphorylation [GO:0046777],
positive regulation of phagocytosis [GO:0050766],
chaperone-mediated protein folding [GO:0061077],
positive regulation of lysosomal membrane permeability [GO:0097214],
maintenance of postsynaptic specialization structure [GO:0098880],
positive regulation of protein refolding [GO:1904592],

Molecular Function:
G-protein coupled receptor binding [GO:0001664],
phosphatidylserine binding [GO:0001786],
RNA binding [GO:0003723],
protein binding [GO:0005515],
ATP binding [GO:0005524],
ATPase activity [GO:0016887],
enzyme binding [GO:0019899],
MHC class II protein complex binding [GO:0023026],
protein binding, bridging [GO:0030674],
heat shock protein binding [GO:0031072],
ubiquitin protein ligase binding [GO:0031625],
protein binding involved in protein folding [GO:0044183],
cadherin binding [GO:0045296],
unfolded protein binding [GO:0051082],
chaperone binding [GO:0051087],
misfolded protein binding [GO:0051787],
C3HC4-type RING finger domain binding [GO:0055131],
clathrin-uncoating ATPase activity [GO:1990833],
nucleotide binding [GO:0000166],
receptor binding [GO:0005102],
transcription factor binding [GO:0008134],
A1 adenosine receptor binding [GO:0031686],
peptide binding [GO:0042277],
ADP binding [GO:0043531],
prostaglandin binding [GO:1904593],

Cellular Component:
Prp19 complex [GO:0000974],
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
spliceosomal complex [GO:0005681],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
lysosome [GO:0005764],
lysosomal membrane [GO:0005765],
late endosome [GO:0005770],
autophagosome [GO:0005776],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
membrane [GO:0016020],
axon [GO:0030424],
dendrite [GO:0030425],
secretory granule lumen [GO:0034774],
melanosome [GO:0042470],
terminal bouton [GO:0043195],
lysosomal lumen [GO:0043202],
perinuclear region of cytoplasm [GO:0048471],
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202],
extracellular exosome [GO:0070062],
blood microparticle [GO:0072562],
lumenal side of lysosomal membrane [GO:0098575],
glutamatergic synapse [GO:0098978],
presynaptic cytosol [GO:0099523],
postsynaptic cytosol [GO:0099524],
postsynaptic specialization membrane [GO:0099634],
ficolin-1-rich granule lumen [GO:1904813],
ribonucleoprotein complex [GO:1990904],
photoreceptor inner segment [GO:0001917],
intracellular [GO:0005622],
microtubule [GO:0005874],
intermediate filament [GO:0005882],
synaptic vesicle [GO:0008021],
cell surface [GO:0009986],
postsynaptic density [GO:0014069],
asymmetric synapse [GO:0032279],
macromolecular complex [GO:0032991],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
dendritic spine [GO:0043197],
dendritic shaft [GO:0043198],
perikaryon [GO:0043204],
myelin sheath [GO:0043209],
neuron spine [GO:0044309],
membrane raft [GO:0045121],
presynapse [GO:0098793],
postsynapse [GO:0098794],
messenger ribonucleoprotein complex [GO:1990124],
lysosomal matrix [GO:1990836],