ANPEP

alanyl aminopeptidase, membrane

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30626320 HBEC Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30977188 MSC Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
angiogenesis [GO:0001525],
proteolysis [GO:0006508],
cell differentiation [GO:0030154],
peptide catabolic process [GO:0043171],
neutrophil degranulation [GO:0043312],
viral entry into host cell [GO:0046718],
multicellular organism development [GO:0007275],
negative regulation of renal sodium excretion [GO:0035814],

Molecular Function:
virus receptor activity [GO:0001618],
aminopeptidase activity [GO:0004177],
metallopeptidase activity [GO:0008237],
zinc ion binding [GO:0008270],
signaling receptor activity [GO:0038023],
peptide binding [GO:0042277],
metalloaminopeptidase activity [GO:0070006],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
extracellular space [GO:0005615],
cytoplasm [GO:0005737],
lysosomal membrane [GO:0005765],
endoplasmic reticulum-Golgi intermediate compartment [GO:0005793],
plasma membrane [GO:0005886],
external side of plasma membrane [GO:0009897],
integral component of membrane [GO:0016021],
secretory granule membrane [GO:0030667],
extracellular exosome [GO:0070062],
membrane [GO:0016020],
brush border membrane [GO:0031526],