HSPA1A

heat shock protein family A (Hsp70) member 1A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945054 IMR-90, primary epithelial cells derived from kidney Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
17332370 HCT 116, MDA-MB-231, MCF 1F, 293T, DU 145, PC-3, HeLa, MCF7 Human NO
19001088 MCF 1A, HCT 116, MDA-MB-231, 293T, DU 145, PC-3, BT-2, Hs 578T, PANC-1, A549, MCF7, OVCAR-5, HeLa Human NO
21297664 MCF 1A Human NO
29548335 Saos-2 Human YES

GO terms:

Biological Process:
mRNA catabolic process [GO:0006402],
response to unfolded protein [GO:0006986],
lysosomal transport [GO:0007041],
negative regulation of cell proliferation [GO:0008285],
positive regulation of gene expression [GO:0010628],
regulation of cell death [GO:0010941],
vesicle-mediated transport [GO:0016192],
negative regulation of cell growth [GO:0030308],
negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512],
regulation of protein ubiquitination [GO:0031396],
negative regulation of protein ubiquitination [GO:0031397],
positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436],
positive regulation of interleukin-8 production [GO:0032757],
positive regulation of RNA splicing [GO:0033120],
cellular response to oxidative stress [GO:0034599],
cellular response to heat [GO:0034605],
cellular response to unfolded protein [GO:0034620],
protein refolding [GO:0042026],
negative regulation of apoptotic process [GO:0043066],
neutrophil degranulation [GO:0043312],
regulation of mRNA stability [GO:0043488],
positive regulation of erythrocyte differentiation [GO:0045648],
ATP metabolic process [GO:0046034],
viral entry into host cell [GO:0046718],
protein stabilization [GO:0050821],
chaperone mediated protein folding requiring cofactor [GO:0051085],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
chaperone-mediated protein complex assembly [GO:0051131],
negative regulation of cell death [GO:0060548],
cellular heat acclimation [GO:0070370],
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434],
positive regulation of microtubule nucleation [GO:0090063],
negative regulation of inclusion body assembly [GO:0090084],
negative regulation of transcription from RNA polymerase II promoter in response to stress [GO:0097201],
regulation of cellular response to heat [GO:1900034],
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029],
regulation of mitotic spindle assembly [GO:1901673],
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236],
positive regulation of endoribonuclease activity [GO:1902380],
positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265],
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240],
telomere maintenance [GO:0000723],
DNA repair [GO:0006281],
protein folding [GO:0006457],
response to heat [GO:0009408],

Molecular Function:
virus receptor activity [GO:0001618],
G-protein coupled receptor binding [GO:0001664],
transcription corepressor activity [GO:0003714],
RNA binding [GO:0003723],
receptor binding [GO:0005102],
protein binding [GO:0005515],
ATP binding [GO:0005524],
ATPase activity [GO:0016887],
enzyme binding [GO:0019899],
heat shock protein binding [GO:0031072],
denatured protein binding [GO:0031249],
ubiquitin protein ligase binding [GO:0031625],
histone deacetylase binding [GO:0042826],
protein binding involved in protein folding [GO:0044183],
cadherin binding [GO:0045296],
protein N-terminus binding [GO:0047485],
unfolded protein binding [GO:0051082],
misfolded protein binding [GO:0051787],
C3HC4-type RING finger domain binding [GO:0055131],
disordered domain specific binding [GO:0097718],
protease binding [GO:0002020],
double-stranded RNA binding [GO:0003725],
NF-kappaB binding [GO:0051059],

Cellular Component:
extracellular region [GO:0005576],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
endoplasmic reticulum [GO:0005783],
centrosome [GO:0005813],
centriole [GO:0005814],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
COP9 signalosome [GO:0008180],
inclusion body [GO:0016234],
aggresome [GO:0016235],
nuclear speck [GO:0016607],
vesicle [GO:0031982],
macromolecular complex [GO:0032991],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
blood microparticle [GO:0072562],
ficolin-1-rich granule lumen [GO:1904813],
ribonucleoprotein complex [GO:1990904],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
membrane raft [GO:0045121],