HSP90AB1

heat shock protein 90 alpha family class B member 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES
31692039 IMR-32 Human NO

GO terms:

Biological Process:
placenta development [GO:0001890],
protein folding [GO:0006457],
xenobiotic metabolic process [GO:0006805],
response to unfolded protein [GO:0006986],
telomere maintenance via telomerase [GO:0007004],
response to salt stress [GO:0009651],
virion attachment to host cell [GO:0019062],
central nervous system neuron axonogenesis [GO:0021955],
establishment of cell polarity [GO:0030010],
positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511],
regulation of protein ubiquitination [GO:0031396],
positive regulation of protein binding [GO:0032092],
negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435],
positive regulation of phosphoprotein phosphatase activity [GO:0032516],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
cellular response to heat [GO:0034605],
cellular response to drug [GO:0035690],
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096],
response to cocaine [GO:0042220],
positive regulation of protein import into nucleus [GO:0042307],
neutrophil degranulation [GO:0043312],
negative regulation of neuron apoptotic process [GO:0043524],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
positive regulation of cell differentiation [GO:0045597],
positive regulation of cell size [GO:0045793],
axon extension [GO:0048675],
protein stabilization [GO:0050821],
chaperone-mediated protein complex assembly [GO:0051131],
negative regulation of protein metabolic process [GO:0051248],
positive regulation of protein kinase B signaling [GO:0051897],
positive regulation of telomerase activity [GO:0051973],
regulation of interferon-gamma-mediated signaling pathway [GO:0060334],
regulation of type I interferon-mediated signaling pathway [GO:0060338],
negative regulation of cell cycle arrest [GO:0071157],
cellular response to interleukin-4 [GO:0071353],
cellular response to organic cyclic compound [GO:0071407],
positive regulation of protein serine/threonine kinase activity [GO:0071902],
fibril organization [GO:0097435],
regulation of cellular response to heat [GO:1900034],
negative regulation of transforming growth factor beta activation [GO:1901389],
negative regulation of proteasomal protein catabolic process [GO:1901799],
positive regulation of tau-protein kinase activity [GO:1902949],
negative regulation of complement-dependent cytotoxicity [GO:1903660],
regulation of cellular protein localization [GO:1903827],
positive regulation of cyclin-dependent protein kinase activity [GO:1904031],
telomerase holoenzyme complex assembly [GO:1905323],
positive regulation of protein localization to cell surface [GO:2000010],
response to organic substance [GO:0010033],
negative regulation of apoptotic process [GO:0043066],

Molecular Function:
UTP binding [GO:0002134],
CTP binding [GO:0002135],
RNA binding [GO:0003723],
double-stranded RNA binding [GO:0003725],
protein binding [GO:0005515],
ATP binding [GO:0005524],
GTP binding [GO:0005525],
sulfonylurea receptor binding [GO:0017098],
protein kinase regulator activity [GO:0019887],
kinase binding [GO:0019900],
protein kinase binding [GO:0019901],
MHC class II protein complex binding [GO:0023026],
nitric-oxide synthase regulator activity [GO:0030235],
TPR domain binding [GO:0030911],
heat shock protein binding [GO:0031072],
ubiquitin protein ligase binding [GO:0031625],
dATP binding [GO:0032564],
peptide binding [GO:0042277],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
histone deacetylase binding [GO:0042826],
ATP-dependent protein binding [GO:0043008],
protein binding involved in protein folding [GO:0044183],
ion channel binding [GO:0044325],
cadherin binding [GO:0045296],
protein dimerization activity [GO:0046983],
tau protein binding [GO:0048156],
unfolded protein binding [GO:0051082],
DNA polymerase binding [GO:0070182],
disordered domain specific binding [GO:0097718],
histone methyltransferase binding [GO:1990226],
nucleotide binding [GO:0000166],
drug binding [GO:0008144],

Cellular Component:
extracellular region [GO:0005576],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
lysosomal membrane [GO:0005765],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
COP9 signalosome [GO:0008180],
cell surface [GO:0009986],
membrane [GO:0016020],
inclusion body [GO:0016234],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
brush border membrane [GO:0031526],
macromolecular complex [GO:0032991],
aryl hydrocarbon receptor complex [GO:0034751],
secretory granule lumen [GO:0034774],
melanosome [GO:0042470],
neuronal cell body [GO:0043025],
dendritic growth cone [GO:0044294],
axonal growth cone [GO:0044295],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
ficolin-1-rich granule lumen [GO:1904813],
HSP90-CDC37 chaperone complex [GO:1990565],
sperm head plasma membrane [GO:1990913],
ooplasm [GO:1990917],
intracellular [GO:0005622],