heat shock protein 90 alpha family class A member 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES
32148389 HDF Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27793846 IMR-90, HFF Human NO
31219154 MCF10A Human NO
31534052 Kidney Mouse YES
31692039 IMR-32 Human NO

GO terms:

Biological Process:
G2/M transition of mitotic cell cycle [GO:0000086],
positive regulation of protein phosphorylation [GO:0001934],
protein folding [GO:0006457],
mitochondrial transport [GO:0006839],
receptor-mediated endocytosis [GO:0006898],
response to unfolded protein [GO:0006986],
telomere maintenance via telomerase [GO:0007004],
response to heat [GO:0009408],
response to cold [GO:0009409],
regulation of G2/M transition of mitotic cell cycle [GO:0010389],
viral process [GO:0016032],
cytokine-mediated signaling pathway [GO:0019221],
central nervous system neuron axonogenesis [GO:0021955],
establishment of cell polarity [GO:0030010],
regulation of protein ubiquitination [GO:0031396],
positive regulation of protein polymerization [GO:0032273],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
cellular response to heat [GO:0034605],
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096],
ERBB2 signaling pathway [GO:0038128],
protein refolding [GO:0042026],
regulation of protein complex assembly [GO:0043254],
neutrophil degranulation [GO:0043312],
protein unfolding [GO:0043335],
protein import into mitochondrial outer membrane [GO:0045040],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
response to antibiotic [GO:0046677],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
axon extension [GO:0048675],
protein stabilization [GO:0050821],
regulation of nitric-oxide synthase activity [GO:0050999],
chaperone-mediated protein complex assembly [GO:0051131],
positive regulation of protein kinase B signaling [GO:0051897],
positive regulation of telomerase activity [GO:0051973],
chaperone-mediated autophagy [GO:0061684],
ciliary basal body docking [GO:0097711],
regulation of cellular response to heat [GO:1900034],
positive regulation of tau-protein kinase activity [GO:1902949],
positive regulation of cellular protein catabolic process [GO:1903364],
regulation of cellular protein localization [GO:1903827],
telomerase holoenzyme complex assembly [GO:1905323],
neuron migration [GO:0001764],
nitric oxide biosynthetic process [GO:0006809],
positive regulation of lamellipodium assembly [GO:0010592],
positive regulation of protein import into nucleus [GO:0042307],
positive regulation of cytotoxic T cell differentiation [GO:0045585],
positive regulation of cell size [GO:0045793],

Molecular Function:
RNA binding [GO:0003723],
protein binding [GO:0005515],
ATP binding [GO:0005524],
ATPase activity [GO:0016887],
MHC class II protein complex binding [GO:0023026],
nitric-oxide synthase regulator activity [GO:0030235],
TPR domain binding [GO:0030911],
ubiquitin protein ligase binding [GO:0031625],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
histone deacetylase binding [GO:0042826],
tau protein binding [GO:0048156],
GTPase binding [GO:0051020],
unfolded protein binding [GO:0051082],
DNA polymerase binding [GO:0070182],
scaffold protein binding [GO:0097110],
disordered domain specific binding [GO:0097718],
protein tyrosine kinase binding [GO:1990782],
nucleotide binding [GO:0000166],
UTP binding [GO:0002134],
CTP binding [GO:0002135],
mRNA binding [GO:0003729],
GTP binding [GO:0005525],
sulfonylurea receptor binding [GO:0017098],
protein phosphatase binding [GO:0019903],
dATP binding [GO:0032564],
protein binding involved in protein folding [GO:0044183],
ion channel binding [GO:0044325],
Rho GDP-dissociation inhibitor binding [GO:0051022],

Cellular Component:
extracellular region [GO:0005576],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
membrane [GO:0016020],
macromolecular complex [GO:0032991],
secretory granule lumen [GO:0034774],
melanosome [GO:0042470],
neuronal cell body [GO:0043025],
lysosomal lumen [GO:0043202],
myelin sheath [GO:0043209],
dendritic growth cone [GO:0044294],
axonal growth cone [GO:0044295],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
endocytic vesicle lumen [GO:0071682],
ficolin-1-rich granule lumen [GO:1904813],
intracellular [GO:0005622],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
brush border membrane [GO:0031526],
ruffle membrane [GO:0032587],
sperm flagellum [GO:0036126],
neuron projection [GO:0043005],
sperm mitochondrial sheath [GO:0097226],
sperm plasma membrane [GO:0097524],