HRas proto-oncogene, GTPase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
10197626 LF1, PA317, BJ Human NO
10763827 Primary keratinocytes derived from skin Mouse NO
1511730 MRC-5 Human NO
15273725 Primary keratinocytes derived from esophagus Human, mouse NO
15492501 U2OS Human NO
17050172 MEF Mouse NO
19403560 IMR-90, MEF Human, mouse NO
19406145 IMR-90 Human NO
19528227 IMR-90 Human NO
19883200 HEK 293 Human NO
19966300 HeLa, U2OS, U-937, primary fibroblasts derived from rat Human, rat NO
21703241 BJ Human NO
21841825 HThy-ori Human NO
21850009 NIH/3T3, BJ Human NO
22733129 MEF, IMR-90 Human, mouse NO
23284910 Primary dermal fibroblasts derived from skin Human NO
23385065 BJ, U2OS Human NO
23685072 BJ, WI-38, IMR-90, 293T, H1299 Human NO
24047696 MCF7, HepG2, MCF 1A Human, mouse NO
24198727 HUVEC Human NO
24213576 Primary keratinocytes derived from mice, HaCat Skin, Colon Human, mouse NO
25535333 MEF, SW872, MDA-MB-231, A549, A-375, NIH/3T3 Human, mouse NO
25778922 293T, A549, NCI-H1792, Hep G2, MEF, COS-7 Liver Human NO
27259243 HMEC, MCF7, ZR-75-1 Human NO
27437940 MCF7 Human NO
30413053 Primary fibroblasts derived from skin Human NO
30988157 IMR-90 Human YES
31695564 Primary epithelial cells derived from prostate, PWR-1E  exercising human skeletal muscle Human NO
31819167 TIG-3 Human NO
31945054 IMR-90 Human YES
32029712 Primary synovial fibroblast Human YES
9054499 IMR-90, WI-38, MEF, REF52 Human, mouse NO

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
liver development [GO:0001889],
positive regulation of protein phosphorylation [GO:0001934],
stimulatory C-type lectin receptor signaling pathway [GO:0002223],
endocytosis [GO:0006897],
chemotaxis [GO:0006935],
cell cycle arrest [GO:0007050],
mitotic cell cycle checkpoint [GO:0007093],
signal transduction [GO:0007165],
cell surface receptor signaling pathway [GO:0007166],
Ras protein signal transduction [GO:0007265],
positive regulation of cell proliferation [GO:0008284],
negative regulation of cell proliferation [GO:0008285],
animal organ morphogenesis [GO:0009887],
negative regulation of gene expression [GO:0010629],
positive regulation of phospholipase C activity [GO:0010863],
positive regulation of cell migration [GO:0030335],
positive regulation of interferon-gamma production [GO:0032729],
negative regulation of GTPase activity [GO:0034260],
response to isolation stress [GO:0035900],
T-helper 1 type immune response [GO:0042088],
defense response to protozoan [GO:0042832],
positive regulation of MAP kinase activity [GO:0043406],
positive regulation of MAPK cascade [GO:0043410],
negative regulation of neuron apoptotic process [GO:0043524],
positive regulation of GTPase activity [GO:0043547],
positive regulation of DNA replication [GO:0045740],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of JNK cascade [GO:0046330],
positive regulation of Ras protein signal transduction [GO:0046579],
ephrin receptor signaling pathway [GO:0048013],
regulation of long-term neuronal synaptic plasticity [GO:0048169],
positive regulation of epithelial cell proliferation [GO:0050679],
T cell receptor signaling pathway [GO:0050852],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to gamma radiation [GO:0071480],
positive regulation of wound healing [GO:0090303],
positive regulation of protein targeting to membrane [GO:0090314],
cellular senescence [GO:0090398],
intrinsic apoptotic signaling pathway [GO:0097193],
positive regulation of ruffle assembly [GO:1900029],
positive regulation of actin cytoskeleton reorganization [GO:2000251],
positive regulation of miRNA metabolic process [GO:2000630],
apoptotic process [GO:0006915],
small GTPase mediated signal transduction [GO:0007264],
cell aging [GO:0007569],
positive regulation of gene expression [GO:0010628],

Molecular Function:
GTPase activity [GO:0003924],
protein binding [GO:0005515],
GTP binding [GO:0005525],
protein C-terminus binding [GO:0008022],
GDP binding [GO:0019003],
macromolecular complex binding [GO:0044877],
nucleotide binding [GO:0000166],

Cellular Component:
Golgi membrane [GO:0000139],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
perinuclear region of cytoplasm [GO:0048471],
glutamatergic synapse [GO:0098978],
membrane [GO:0016020],
intracellular membrane-bounded organelle [GO:0043231],