HPS1 biogenesis of lysosomal organelles complex 3 subunit 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
33296652 heart heart Human NO

GO terms:

Biological Process:
lysosome organization [GO:0007040],
visual perception [GO:0007601],
response to stimulus [GO:0050896],
melanosome assembly [GO:1903232],
cell morphogenesis [GO:0000902],
respiratory system process [GO:0003016],
cellular zinc ion homeostasis [GO:0006882],
inflammatory response [GO:0006954],
organelle organization [GO:0006996],
spermatogenesis [GO:0007283],
single fertilization [GO:0007338],
blood coagulation [GO:0007596],
gene expression [GO:0010467],
melanocyte differentiation [GO:0030318],
lung development [GO:0030324],
positive regulation of natural killer cell activation [GO:0032816],
secretion of lysosomal enzymes [GO:0033299],
pigmentation [GO:0043473],
eye pigmentation [GO:0048069],
retina development in camera-type eye [GO:0060041],
lung morphogenesis [GO:0060425],

Molecular Function:
guanyl-nucleotide exchange factor activity [GO:0005085],
protein binding [GO:0005515],
protein dimerization activity [GO:0046983],

Cellular Component:
cytoplasm [GO:0005737],
lysosome [GO:0005764],
cytosol [GO:0005829],
BLOC-3 complex [GO:0031085],
cytoplasmic vesicle [GO:0031410],