anoctamin 6

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31148378 MRC-5 Human YES

GO terms:

Biological Process:
dendritic cell chemotaxis [GO:0002407],
activation of blood coagulation via clotting cascade [GO:0002543],
ion transport [GO:0006811],
cation transport [GO:0006812],
chloride transport [GO:0006821],
lipid transport [GO:0006869],
blood coagulation [GO:0007596],
phospholipid scrambling [GO:0017121],
positive regulation of bone mineralization [GO:0030501],
bleb assembly [GO:0032060],
regulation of ion transmembrane transport [GO:0034765],
positive regulation of ion transmembrane transport [GO:0034767],
purinergic nucleotide receptor signaling pathway [GO:0035590],
bone mineralization involved in bone maturation [GO:0035630],
sodium ion transmembrane transport [GO:0035725],
positive regulation of apoptotic process [GO:0043065],
phospholipid translocation [GO:0045332],
negative regulation of cell volume [GO:0045794],
pore complex assembly [GO:0046931],
transmembrane transport [GO:0055085],
positive regulation of phagocytosis, engulfment [GO:0060100],
calcium activated phospholipid scrambling [GO:0061588],
calcium activated phosphatidylserine scrambling [GO:0061589],
calcium activated phosphatidylcholine scrambling [GO:0061590],
calcium activated galactosylceramide scrambling [GO:0061591],
calcium ion transmembrane transport [GO:0070588],
phosphatidylserine exposure on apoptotic cell surface [GO:0070782],
positive regulation of monocyte chemotaxis [GO:0090026],
phosphatidylserine exposure on blood platelet [GO:0097045],
chloride transmembrane transport [GO:1902476],
positive regulation of potassium ion export across plasma membrane [GO:1903766],
positive regulation of endothelial cell apoptotic process [GO:2000353],
ion transmembrane transport [GO:0034220],
neutrophil degranulation [GO:0043312],

Molecular Function:
calcium activated cation channel activity [GO:0005227],
intracellular calcium activated chloride channel activity [GO:0005229],
voltage-gated ion channel activity [GO:0005244],
voltage-gated chloride channel activity [GO:0005247],
chloride channel activity [GO:0005254],
phospholipid scramblase activity [GO:0017128],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
metal ion binding [GO:0046872],
protein dimerization activity [GO:0046983],
protein binding [GO:0005515],

Cellular Component:
cytosol [GO:0005829],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
chloride channel complex [GO:0034707],
cell surface [GO:0009986],
specific granule membrane [GO:0035579],
extracellular exosome [GO:0070062],
tertiary granule membrane [GO:0070821],