HMOX1

heme oxygenase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
17295091 WI-38 Human NO
21678067 CCCL-1 Human NO
31945125 Primary astrocytes derived from brain Human YES
32029712 Primary synovial fibroblast Human YES
32042076 Primary fibroblasts derived from skin Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
22155307 Primary osteoblasts Human NO
25175370 Primary chondrocytes derived from bone Rat NO
30048241 HUVEC Aorta Human, rat NO
30683864 Spleen, Colon Rat NO
31635416 Primary fibroblasts derived from skin Human YES

GO terms:

Biological Process:
angiogenesis [GO:0001525],
endothelial cell proliferation [GO:0001935],
wound healing involved in inflammatory response [GO:0002246],
negative regulation of leukocyte migration [GO:0002686],
heme oxidation [GO:0006788],
cellular iron ion homeostasis [GO:0006879],
response to oxidative stress [GO:0006979],
small GTPase mediated signal transduction [GO:0007264],
excretion [GO:0007588],
regulation of blood pressure [GO:0008217],
cell death [GO:0008219],
intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630],
negative regulation of muscle cell apoptotic process [GO:0010656],
smooth muscle hyperplasia [GO:0014806],
positive regulation of macroautophagy [GO:0016239],
negative regulation of macroautophagy [GO:0016242],
cytokine-mediated signaling pathway [GO:0019221],
cellular response to nutrient [GO:0031670],
negative regulation of mast cell cytokine production [GO:0032764],
erythrocyte homeostasis [GO:0034101],
low-density lipoprotein particle clearance [GO:0034383],
regulation of transcription from RNA polymerase II promoter in response to iron [GO:0034395],
cellular response to heat [GO:0034605],
response to nicotine [GO:0035094],
intracellular signal transduction [GO:0035556],
heme catabolic process [GO:0042167],
response to hydrogen peroxide [GO:0042542],
positive regulation of apoptotic process [GO:0043065],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
negative regulation of mast cell degranulation [GO:0043305],
negative regulation of DNA binding [GO:0043392],
negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433],
negative regulation of neuron apoptotic process [GO:0043524],
regulation of transcription from RNA polymerase II promoter in response to oxidative stress [GO:0043619],
response to estrogen [GO:0043627],
positive regulation of chemokine biosynthetic process [GO:0045080],
regulation of angiogenesis [GO:0045765],
positive regulation of angiogenesis [GO:0045766],
positive regulation of smooth muscle cell proliferation [GO:0048661],
negative regulation of smooth muscle cell proliferation [GO:0048662],
regulation of sequence-specific DNA binding transcription factor activity [GO:0051090],
iron ion homeostasis [GO:0055072],
cellular response to arsenic-containing substance [GO:0071243],
cellular response to cadmium ion [GO:0071276],
cellular response to hypoxia [GO:0071456],
cellular response to cisplatin [GO:0072719],
positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050],
liver regeneration [GO:0097421],
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042],
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589],
negative regulation of epithelial cell apoptotic process [GO:1904036],
negative regulation of vascular smooth muscle cell proliferation [GO:1904706],
response to hypoxia [GO:0001666],
apoptotic process [GO:0006915],
negative regulation of cell proliferation [GO:0008285],
heme metabolic process [GO:0042168],
oxidation-reduction process [GO:0055114],

Molecular Function:
heme oxygenase (decyclizing) activity [GO:0004392],
phospholipase D activity [GO:0004630],
structural molecule activity [GO:0005198],
protein binding [GO:0005515],
enzyme binding [GO:0019899],
heme binding [GO:0020037],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
metal ion binding [GO:0046872],
oxidoreductase activity [GO:0016491],

Cellular Component:
extracellular space [GO:0005615],
nucleus [GO:0005634],
nucleolus [GO:0005730],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
cytosol [GO:0005829],
caveola [GO:0005901],
membrane [GO:0016020],
perinuclear region of cytoplasm [GO:0048471],
intracellular membrane-bounded organelle [GO:0043231],