HMGB1

high mobility group box 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
23649808 HCA2, IMR-90, WI-38, MEF, AT2SF, AT5823, HMEC Human, mouse NO
25469638 Primary cells derived from amniotic fluid Human NO
31940439 Human NO
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
25051367 A-375, G-361, SK-MEL-28 Human NO
29449545 HMEC, MRC-5, IMR-90, 293GP, WI-38, HUVEC Human NO
30735837 Retina Mouse NO
30900385 Intervertebral disc Mouse NO
31633821 Primary melanocytes derived from skin Human NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
myeloid dendritic cell activation [GO:0001773],
activation of innate immune response [GO:0002218],
toll-like receptor signaling pathway [GO:0002224],
dendritic cell chemotaxis [GO:0002407],
inflammatory response to antigenic stimulus [GO:0002437],
regulation of tolerance induction [GO:0002643],
regulation of T cell mediated immune response to tumor cell [GO:0002840],
DNA topological change [GO:0006265],
apoptotic DNA fragmentation [GO:0006309],
DNA recombination [GO:0006310],
chromatin remodeling [GO:0006338],
chromatin silencing [GO:0006342],
regulation of transcription, DNA-templated [GO:0006355],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
autophagy [GO:0006914],
inflammatory response [GO:0006954],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
regulation of receptor activity [GO:0010469],
positive regulation of autophagy [GO:0010508],
viral process [GO:0016032],
negative regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0017055],
neuron projection development [GO:0031175],
regulation of restriction endodeoxyribonuclease activity [GO:0032072],
DNA geometric change [GO:0032392],
positive regulation of mismatch repair [GO:0032425],
developmental process [GO:0032502],
negative regulation of interferon-gamma production [GO:0032689],
positive regulation of interleukin-10 production [GO:0032733],
positive regulation of interleukin-12 production [GO:0032735],
positive regulation of interleukin-6 production [GO:0032755],
positive regulation of interleukin-8 production [GO:0032757],
positive regulation of tumor necrosis factor production [GO:0032760],
V(D)J recombination [GO:0033151],
positive regulation of toll-like receptor 9 signaling pathway [GO:0034165],
T-helper 1 cell activation [GO:0035711],
positive regulation of activated T cell proliferation [GO:0042104],
positive regulation of apoptotic process [GO:0043065],
apoptotic cell clearance [GO:0043277],
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280],
neutrophil degranulation [GO:0043312],
negative regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043371],
positive regulation of DNA binding [GO:0043388],
positive regulation of MAPK cascade [GO:0043410],
positive regulation of blood vessel endothelial cell migration [GO:0043536],
negative regulation of blood vessel endothelial cell migration [GO:0043537],
T-helper 1 cell differentiation [GO:0045063],
innate immune response [GO:0045087],
positive regulation of innate immune response [GO:0045089],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of JNK cascade [GO:0046330],
positive regulation of interleukin-1 secretion [GO:0050716],
positive regulation of interleukin-1 beta secretion [GO:0050718],
positive chemotaxis [GO:0050918],
DNA ligation involved in DNA repair [GO:0051103],
positive regulation of DNA ligation [GO:0051106],
cell chemotaxis [GO:0060326],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to lipopolysaccharide [GO:0071222],
positive regulation of monocyte chemotaxis [GO:0090026],
neutrophil clearance [GO:0097350],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
positive regulation of interferon-alpha secretion [GO:1902741],
positive regulation of vascular endothelial cell proliferation [GO:1905564],
tumor necrosis factor secretion [GO:1990774],
positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343],
negative regulation of apoptotic cell clearance [GO:2000426],
positive regulation of interleukin-6 secretion [GO:2000778],
positive regulation of dendritic cell differentiation [GO:2001200],
eye development [GO:0001654],
positive regulation of protein phosphorylation [GO:0001934],
endothelial cell proliferation [GO:0001935],
positive regulation of mesenchymal cell proliferation [GO:0002053],
adaptive immune response [GO:0002250],
plasmacytoid dendritic cell activation [GO:0002270],
macrophage activation involved in immune response [GO:0002281],
immune system process [GO:0002376],
DNA repair [GO:0006281],
base-excision repair [GO:0006284],
chemotaxis [GO:0006935],
cellular response to DNA damage stimulus [GO:0006974],
lung development [GO:0030324],
positive regulation of cell migration [GO:0030335],
chromatin assembly [GO:0031497],
positive regulation of interferon-alpha production [GO:0032727],
positive regulation of interferon-beta production [GO:0032728],
positive regulation of toll-like receptor 2 signaling pathway [GO:0034137],
positive regulation of toll-like receptor 4 signaling pathway [GO:0034145],
endothelial cell chemotaxis [GO:0035767],
positive regulation of myeloid cell differentiation [GO:0045639],
positive regulation of glycogen catabolic process [GO:0045819],
positive regulation of mitotic cell cycle [GO:0045931],
induction of positive chemotaxis [GO:0050930],
response to glucocorticoid [GO:0051384],
positive regulation of monocyte chemotactic protein-1 production [GO:0071639],
positive regulation of wound healing [GO:0090303],
cellular response to interleukin-7 [GO:0098761],
positive regulation of sprouting angiogenesis [GO:1903672],
regulation of nucleotide-excision repair [GO:2000819],

Molecular Function:
four-way junction DNA binding [GO:0000400],
bubble DNA binding [GO:0000405],
transcription regulatory region sequence-specific DNA binding [GO:0000976],
lipopolysaccharide binding [GO:0001530],
phosphatidylserine binding [GO:0001786],
chromatin binding [GO:0003682],
damaged DNA binding [GO:0003684],
double-stranded DNA binding [GO:0003690],
single-stranded DNA binding [GO:0003697],
transcription coactivator activity [GO:0003713],
RNA binding [GO:0003723],
cytokine activity [GO:0005125],
integrin binding [GO:0005178],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
DNA binding, bending [GO:0008301],
lyase activity [GO:0016829],
C-X-C chemokine binding [GO:0019958],
chemoattractant activity [GO:0042056],
RAGE receptor binding [GO:0050786],
DNA polymerase binding [GO:0070182],
repressing transcription factor binding [GO:0070491],
supercoiled DNA binding [GO:0097100],
open form four-way junction DNA binding [GO:0000401],
crossed form four-way junction DNA binding [GO:0000402],
DNA binding [GO:0003677],
bent DNA binding [GO:0003681],
double-stranded RNA binding [GO:0003725],
single-stranded RNA binding [GO:0003727],
heparin binding [GO:0008201],
calcium-dependent protein kinase regulator activity [GO:0010858],
protein kinase activator activity [GO:0030295],

Cellular Component:
nuclear chromatin [GO:0000790],
condensed chromosome [GO:0000793],
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
endosome [GO:0005768],
endoplasmic reticulum-Golgi intermediate compartment [GO:0005793],
cell surface [GO:0009986],
transcriptional repressor complex [GO:0017053],
secretory granule lumen [GO:0034774],
alphav-beta3 integrin-HMGB1 complex [GO:0035868],
ficolin-1-rich granule lumen [GO:1904813],
chromosome [GO:0005694],
early endosome [GO:0005769],
plasma membrane [GO:0005886],
membrane [GO:0016020],
neuron projection [GO:0043005],