HMGB1

high mobility group box 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
23649808 HCA2, IMR-90, WI-38, MEF, AT2SF, AT5823, HMEC Human, mouse NO
25469638 Primary cells derived from amniotic fluid Human NO
31940439 Human NO
31945054 IMR-90 Human YES
33470505 brain Mouse No

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
25051367 A-375, G-361, SK-MEL-28 Human NO
29449545 HMEC, MRC-5, IMR-90, 293GP, WI-38, HUVEC Human NO
30735837 Retina Mouse NO
30900385 Intervertebral disc Mouse NO
31633821 Primary melanocytes derived from skin Human NO
31945125 Primary astrocytes derived from brain Human YES
32523550 HCASMC Human No
31915373 Hheart_LA_VS healthy nan Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
myeloid dendritic cell activation [GO:0001773],
activation of innate immune response [GO:0002218],
toll-like receptor signaling pathway [GO:0002224],
dendritic cell chemotaxis [GO:0002407],
inflammatory response to antigenic stimulus [GO:0002437],
regulation of tolerance induction [GO:0002643],
regulation of T cell mediated immune response to tumor cell [GO:0002840],
DNA topological change [GO:0006265],
apoptotic DNA fragmentation [GO:0006309],
DNA recombination [GO:0006310],
chromatin remodeling [GO:0006338],
chromatin silencing [GO:0006342],
regulation of transcription, DNA-templated [GO:0006355],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
autophagy [GO:0006914],
inflammatory response [GO:0006954],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
regulation of receptor activity [GO:0010469],
positive regulation of autophagy [GO:0010508],
viral process [GO:0016032],
negative regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0017055],
neuron projection development [GO:0031175],
regulation of restriction endodeoxyribonuclease activity [GO:0032072],
DNA geometric change [GO:0032392],
positive regulation of mismatch repair [GO:0032425],
developmental process [GO:0032502],
negative regulation of interferon-gamma production [GO:0032689],
positive regulation of interleukin-10 production [GO:0032733],
positive regulation of interleukin-12 production [GO:0032735],
positive regulation of interleukin-6 production [GO:0032755],
positive regulation of interleukin-8 production [GO:0032757],
positive regulation of tumor necrosis factor production [GO:0032760],
V(D)J recombination [GO:0033151],
positive regulation of toll-like receptor 9 signaling pathway [GO:0034165],
T-helper 1 cell activation [GO:0035711],
positive regulation of activated T cell proliferation [GO:0042104],
positive regulation of apoptotic process [GO:0043065],
apoptotic cell clearance [GO:0043277],
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280],
neutrophil degranulation [GO:0043312],
negative regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043371],
positive regulation of DNA binding [GO:0043388],
positive regulation of MAPK cascade [GO:0043410],
positive regulation of blood vessel endothelial cell migration [GO:0043536],
negative regulation of blood vessel endothelial cell migration [GO:0043537],
T-helper 1 cell differentiation [GO:0045063],
innate immune response [GO:0045087],
positive regulation of innate immune response [GO:0045089],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of JNK cascade [GO:0046330],
positive regulation of interleukin-1 secretion [GO:0050716],
positive regulation of interleukin-1 beta secretion [GO:0050718],
positive chemotaxis [GO:0050918],
DNA ligation involved in DNA repair [GO:0051103],
positive regulation of DNA ligation [GO:0051106],
cell chemotaxis [GO:0060326],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to lipopolysaccharide [GO:0071222],
positive regulation of monocyte chemotaxis [GO:0090026],
neutrophil clearance [GO:0097350],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
positive regulation of interferon-alpha secretion [GO:1902741],
positive regulation of vascular endothelial cell proliferation [GO:1905564],
tumor necrosis factor secretion [GO:1990774],
positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343],
negative regulation of apoptotic cell clearance [GO:2000426],
positive regulation of interleukin-6 secretion [GO:2000778],
positive regulation of dendritic cell differentiation [GO:2001200],
eye development [GO:0001654],
positive regulation of protein phosphorylation [GO:0001934],
endothelial cell proliferation [GO:0001935],
positive regulation of mesenchymal cell proliferation [GO:0002053],
adaptive immune response [GO:0002250],
plasmacytoid dendritic cell activation [GO:0002270],
macrophage activation involved in immune response [GO:0002281],
immune system process [GO:0002376],
DNA repair [GO:0006281],
base-excision repair [GO:0006284],
chemotaxis [GO:0006935],
cellular response to DNA damage stimulus [GO:0006974],
lung development [GO:0030324],
positive regulation of cell migration [GO:0030335],
chromatin assembly [GO:0031497],
positive regulation of interferon-alpha production [GO:0032727],
positive regulation of interferon-beta production [GO:0032728],
positive regulation of toll-like receptor 2 signaling pathway [GO:0034137],
positive regulation of toll-like receptor 4 signaling pathway [GO:0034145],
endothelial cell chemotaxis [GO:0035767],
positive regulation of myeloid cell differentiation [GO:0045639],
positive regulation of glycogen catabolic process [GO:0045819],
positive regulation of mitotic cell cycle [GO:0045931],
induction of positive chemotaxis [GO:0050930],
response to glucocorticoid [GO:0051384],
positive regulation of monocyte chemotactic protein-1 production [GO:0071639],
positive regulation of wound healing [GO:0090303],
cellular response to interleukin-7 [GO:0098761],
positive regulation of sprouting angiogenesis [GO:1903672],
regulation of nucleotide-excision repair [GO:2000819],

Molecular Function:
four-way junction DNA binding [GO:0000400],
bubble DNA binding [GO:0000405],
transcription regulatory region sequence-specific DNA binding [GO:0000976],
lipopolysaccharide binding [GO:0001530],
phosphatidylserine binding [GO:0001786],
chromatin binding [GO:0003682],
damaged DNA binding [GO:0003684],
double-stranded DNA binding [GO:0003690],
single-stranded DNA binding [GO:0003697],
transcription coactivator activity [GO:0003713],
RNA binding [GO:0003723],
cytokine activity [GO:0005125],
integrin binding [GO:0005178],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
DNA binding, bending [GO:0008301],
lyase activity [GO:0016829],
C-X-C chemokine binding [GO:0019958],
chemoattractant activity [GO:0042056],
RAGE receptor binding [GO:0050786],
DNA polymerase binding [GO:0070182],
repressing transcription factor binding [GO:0070491],
supercoiled DNA binding [GO:0097100],
open form four-way junction DNA binding [GO:0000401],
crossed form four-way junction DNA binding [GO:0000402],
DNA binding [GO:0003677],
bent DNA binding [GO:0003681],
double-stranded RNA binding [GO:0003725],
single-stranded RNA binding [GO:0003727],
heparin binding [GO:0008201],
calcium-dependent protein kinase regulator activity [GO:0010858],
protein kinase activator activity [GO:0030295],

Cellular Component:
nuclear chromatin [GO:0000790],
condensed chromosome [GO:0000793],
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
endosome [GO:0005768],
endoplasmic reticulum-Golgi intermediate compartment [GO:0005793],
cell surface [GO:0009986],
transcriptional repressor complex [GO:0017053],
secretory granule lumen [GO:0034774],
alphav-beta3 integrin-HMGB1 complex [GO:0035868],
ficolin-1-rich granule lumen [GO:1904813],
chromosome [GO:0005694],
early endosome [GO:0005769],
plasma membrane [GO:0005886],
membrane [GO:0016020],
neuron projection [GO:0043005],