AACS

acetoacetyl-CoA synthetase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31148378 MRC-5 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
liver development [GO:0001889],
fatty acid metabolic process [GO:0006631],
response to nutrient [GO:0007584],
response to purine-containing compound [GO:0014074],
positive regulation of insulin secretion [GO:0032024],
response to oleic acid [GO:0034201],
response to starvation [GO:0042594],
response to ethanol [GO:0045471],
ketone body biosynthetic process [GO:0046951],
white fat cell differentiation [GO:0050872],
adipose tissue development [GO:0060612],
cellular response to glucose stimulus [GO:0071333],
cellular response to testosterone stimulus [GO:0071394],
cellular response to cholesterol [GO:0071397],
lipid metabolic process [GO:0006629],
response to organonitrogen compound [GO:0010243],
response to organic cyclic compound [GO:0014070],
response to drug [GO:0042493],

Molecular Function:
protein binding [GO:0005515],
ATP binding [GO:0005524],
acetoacetate-CoA ligase activity [GO:0030729],
butyrate-CoA ligase activity [GO:0047760],
nucleotide binding [GO:0000166],
catalytic activity [GO:0003824],
ligase activity [GO:0016874],

Cellular Component:
cytosol [GO:0005829],
cytoplasm [GO:0005737],