Search type: go_term

Results for query: zinc ion binding

Gene Symbol Gene Name Links to Senescence
AARS alanyl-tRNA synthetase
D: 1
AARS2 alanyl-tRNA synthetase 2, mitochondrial
U: 1
D: 2
ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
U: 1
ACE2 angiotensin I converting enzyme 2
U: 1
ACER3 alkaline ceramidase 3
D: 1
ADA adenosine deaminase
D: 1
ADAM8 a disintegrin and metallopeptidase domain 8
D: 1
ADAMTS1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
D: 1
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif 13
U: 2
ADAMTS15 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15
U: 2
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif 3
U: 1
ADAMTS5 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
U: 1
ADAMTS8 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8
U: 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
D: 1
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
D: 2
AGBL2 ATP/GTP binding protein-like 2
U: 1
ALAD aminolevulinate, delta-, dehydratase
U: 1
ALKBH8 alkB homolog 8, tRNA methyltransferase
D: 2
ALPI alkaline phosphatase, intestinal
U: 2
ALPP alkaline phosphatase, placental
U: 2
D: 1
ANPEP alanyl (membrane) aminopeptidase
U: 1
AOC1 amine oxidase, copper-containing 1
U: 2
APEX2 apurinic/apyrimidinic endonuclease 2
D: 1
APIP APAF1 interacting protein
D: 1
APOBEC3B apolipoprotein B mRNA editing enzyme catalytic subunit 3B
U: 1
D: 3
AR androgen receptor
U: 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2
D: 1
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
D: 1
ATP13A2 ATPase cation transporting 13A2
U: 2
D: 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase)
U: 2
BLM Bloom syndrome, RecQ like helicase
D: 4
BLVRA biliverdin reductase A
D: 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
D: 26
BMP1 bone morphogenetic protein 1
U: 2
BRAP BRCA1 associated protein
U: 1
BRCA1 breast cancer 1, early onset
U: 2
D: 7
BIRC5 baculoviral IAP repeat-containing 5
U: 1
D: 8
C11ORF54 chromosome 11 open reading frame 54
U: 1
D: 1
CA11 carbonic anhydrase 11
U: 3
CA12 carbonic anhydrase 12
D: 1
CA14 carbonic anhydrase 14
D: 1
CA2 carbonic anhydrase 2
U: 1
D: 1
CA4 carbonic anhydrase 4
U: 1
CA7 carbonic anhydrase 7
U: 1
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
D: 1
CALR calreticulin
D: 2
CBLC Cbl proto-oncogene C
D: 1
CDADC1 cytidine and dCMP deaminase domain containing 1
U: 1
CHD3 chromodomain helicase DNA binding protein 3
D: 1
CHD4 chromodomain helicase DNA binding protein 4
U: 1
CHORDC1 cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1
D: 1
CHURC1 churchill domain containing 1
U: 1
CPA4 carboxypeptidase A4
U: 3
CPA5 carboxypeptidase A5
U: 1
CPD carboxypeptidase D
U: 1
CPE carboxypeptidase E
U: 2
CPM carboxypeptidase M
D: 3
CPXM1 carboxypeptidase X 1 (M14 family)
D: 1
CREBBP CREB binding protein
U: 1
D: 1
CRYZ crystallin, zeta
D: 2
CSRP1 cysteine and glycine rich protein 1
U: 1
D: 1
CTCF CCCTC-binding factor
D: 1
CXXC1 CXXC finger 1 (PHD domain)
D: 1
CXXC4 CXXC finger 4
U: 2
CYLD CYLD lysine 63 deubiquitinase
U: 1
DBF4 DBF4 zinc finger
D: 2
DBF4B DBF4 zinc finger B
D: 2
DCTD dCMP deaminase
D: 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
U: 1
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
U: 1
DNAJC21 DnaJ heat shock protein family (Hsp40) member C21
D: 1
DNMT1 DNA methyltransferase (cytosine-5) 1
U: 1
D: 5
DPEP1 dipeptidase 1
D: 2
DPF1 D4, zinc and double PHD fingers family 1
U: 2
D: 1
DTNA dystrobrevin alpha
D: 1
DTX4 deltex 4, E3 ubiquitin ligase
U: 1
D: 1
DUSP12 dual specificity phosphatase 12
D: 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
U: 1
D: 1
ECE1 endothelin converting enzyme 1
U: 1
EGR1 early growth response 1
U: 4
D: 3
EHMT1 euchromatic histone methyltransferase 1
D: 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
U: 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
U: 3
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3
D: 1
EP300 E1A binding protein p300
U: 3
D: 4
EPRS glutamyl-prolyl-tRNA synthetase
D: 1
ERAP2 endoplasmic reticulum aminopeptidase 2
U: 1
ESR1 estrogen receptor 1 (alpha)
U: 1
D: 4
ESR2 estrogen receptor 2 (beta)
U: 1
D: 1
ESRRB estrogen related receptor, beta
U: 1
FNTB farnesyltransferase, CAAX box, beta
D: 1
GATA4 GATA binding protein 4
U: 3
GATA6 GATA binding protein 6
U: 1
GCH1 GTP cyclohydrolase 1
U: 1
GRIN2A glutamate receptor, ionotropic, NMDA2A (epsilon 1)
U: 1
GTF2H2 general transcription factor II H, polypeptide 2
D: 1
GTF2H2C GTF2H2 family member C
D: 1
HDAC4 histone deacetylase 4
U: 1
D: 3
HDAC6 histone deacetylase 6
D: 1
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
D: 1
IFIH1 interferon induced with helicase C domain 1
U: 1
KAT6A K(lysine) acetyltransferase 6A
D: 5
KAT7 K(lysine) acetyltransferase 7
D: 1
KDM1B lysine (K)-specific demethylase 1B
D: 1
KDM2B lysine (K)-specific demethylase 2B
D: 3
KDM4A lysine (K)-specific demethylase 4A
D: 2
KDM4C lysine (K)-specific demethylase 4C
D: 1
KDM5A lysine (K)-specific demethylase 5A
D: 2
KDM5B lysine (K)-specific demethylase 5B
U: 2
D: 1
KLF4 Kruppel like factor 4
U: 3
D: 3
KMT2A lysine (K)-specific methyltransferase 2A
U: 1
D: 1
KNG1 kininogen 1
U: 1
L3MBTL1 L3MBTL1 histone methyl-lysine binding protein
U: 1
LANCL1 LanC (bacterial lantibiotic synthetase component C)-like 1
U: 1
LIG3 ligase III, DNA, ATP-dependent
D: 2
LMCD1 LIM and cysteine-rich domains 1
U: 2
D: 1
LNPEP leucyl/cystinyl aminopeptidase
D: 1
LOC440434 aminopeptidase puromycin sensitive pseudogene
U: 1
MARCH1 membrane-associated ring finger (C3HC4) 1
D: 1
MARCH10 membrane associated ring-CH-type finger 10
D: 1
MARCH11 membrane-associated ring finger (C3HC4) 11
U: 1
MARCH2 membrane-associated ring finger (C3HC4) 2
U: 1
MARCH3 membrane-associated ring finger (C3HC4) 3
U: 2
D: 1
MARCH5 membrane-associated ring finger (C3HC4) 5
U: 1
D: 1
MARCH6 membrane-associated ring finger (C3HC4) 6
U: 1
MBD1 methyl-CpG binding domain protein 1
D: 1
MBTD1 mbt domain containing 1
U: 1
MDM2 transformed mouse 3T3 cell double minute 2
U: 3
D: 11
MDM4 MDM4 regulator of p53
U: 1
D: 1
MID1 midline 1
U: 1
D: 1
MME membrane metallo endopeptidase
D: 1
MMP1 matrix metallopeptidase 1
D: 2
MMP10 matrix metallopeptidase 10
D: 1
MMP11 matrix metallopeptidase 11
U: 1
MMP13 matrix metallopeptidase 13
U: 3
MMP14 matrix metallopeptidase 14 (membrane-inserted)
U: 1
D: 1
MMP15 matrix metallopeptidase 15
U: 1
MMP20 matrix metallopeptidase 20 (enamelysin)
U: 1
MMP24 matrix metallopeptidase 24
U: 2
MMP28 matrix metallopeptidase 28
U: 1
MMP3 matrix metallopeptidase 3
U: 1
MMP7 matrix metallopeptidase 7
D: 2
MMP9 matrix metallopeptidase 9
U: 2
D: 1
MORC3 microrchidia 3
U: 1
D: 1
MORC4 microrchidia 4
D: 1
MSRB1 methionine sulfoxide reductase B1
U: 1
MT1E metallothionein 1E
D: 1
MT1G metallothionein 1G
U: 1
MT1M metallothionein 1M
D: 1
MT1X metallothionein 1X
U: 1
D: 1
MT2A metallothionein 2A
U: 2
D: 1
MT3 metallothionein 3
U: 1
MYNN myoneurin
D: 2
MYT1 myelin transcription factor 1
U: 2
MYBBP1A MYB binding protein (P160) 1a
D: 2
NANOS1 nanos C2HC-type zinc finger 1
U: 1
NEIL1 nei endonuclease VIII-like 1 (E. coli)
U: 1
NEIL2 nei like 2 (E. coli)
U: 1
D: 1
NEIL3 nei like 3 (E. coli)
D: 4
NFX1 nuclear transcription factor, X-box binding 1
D: 1
NFXL1 nuclear transcription factor, X-box binding like 1
D: 2
NPEPPS aminopeptidase puromycin sensitive
U: 2
NR1D1 nuclear receptor subfamily 1, group D, member 1
U: 1
D: 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
D: 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
D: 2
NR1I2 nuclear receptor subfamily 1, group I, member 2
U: 1
NR1I3 nuclear receptor subfamily 1, group I, member 3
D: 1
NR2C1 nuclear receptor subfamily 2, group C, member 1
U: 1
NR2C2 nuclear receptor subfamily 2, group C, member 2
U: 1
D: 1
NR2E1 nuclear receptor subfamily 2, group E, member 1
D: 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
D: 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
U: 1
NR3C1 nuclear receptor subfamily 3, group C, member 1
U: 1
NR3C2 nuclear receptor subfamily 3, group C, member 2
U: 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
U: 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
D: 1
NR5A1 nuclear receptor subfamily 5, group A, member 1
D: 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
U: 1
NSD1 nuclear receptor-binding SET-domain protein 1
D: 1
OTUD7B OTU domain containing 7B
D: 1
P2RX4 purinergic receptor P2X, ligand-gated ion channel 4
D: 1
P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5
U: 1
D: 1
PAM peptidylglycine alpha-amidating monooxygenase
U: 1
PAPPA pappalysin 1
D: 1
PAPPA2 pappalysin 2
D: 1
PARP1 poly (ADP-ribose) polymerase family, member 1
U: 3
D: 3
PDE2A phosphodiesterase 2A, cGMP-stimulated
D: 1
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
U: 1
PGR progesterone receptor
U: 3
D: 1
PHC1 polyhomeotic 1
D: 2
PHC2 polyhomeotic 2
D: 1
PHF8 PHD finger protein 8
U: 1
PIAS1 protein inhibitor of activated STAT 1
U: 1
PIAS4 protein inhibitor of activated STAT 4
U: 1
PML promyelocytic leukemia
U: 11
D: 2
POLE polymerase (DNA directed), epsilon
D: 1
POLR1A polymerase (RNA) I polypeptide A
D: 1
PPARA peroxisome proliferator activated receptor alpha
D: 3
PPARD peroxisome proliferator activator receptor delta
U: 3
D: 3
PPARG peroxisome proliferator activated receptor gamma
U: 3
D: 3
PRDM4 PR/SET domain 4
D: 1
PRICKLE1 prickle planar cell polarity protein 1
D: 1
PRICKLE2 prickle planar cell polarity protein 2
U: 1
PRICKLE4 prickle planar cell polarity protein 4
U: 2
PRKCA protein kinase C, alpha
U: 3
D: 1
PRKN parkin RBR E3 ubiquitin protein ligase
U: 2
PTER phosphotriesterase related
D: 1
PTGR2 prostaglandin reductase 2
U: 1
PTPN1 protein tyrosine phosphatase, non-receptor type 1
U: 1
PTCH1 patched 1
D: 1
QPCT glutaminyl-peptide cyclotransferase (glutaminyl cyclase)
U: 1
QPCTL glutaminyl-peptide cyclotransferase-like
D: 1
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2
D: 1
RABGGTA Rab geranylgeranyl transferase, a subunit
U: 1
RABIF RAB interacting factor
U: 1
RARB retinoic acid receptor, beta
U: 1
RASSF1 Ras association domain family member 1
U: 1
D: 2
RBAK RB associated KRAB zinc finger
U: 1
RBX1 ring-box 1
D: 2
RC3H1 RING CCCH (C3H) domains 1
U: 1
RGN regucalcin
U: 1
D: 3
RNF125 ring finger protein 125
U: 1
D: 1
RNF139 ring finger protein 139
U: 1
RNF145 ring finger protein 145
U: 1
RNF165 ring finger protein 165
U: 2
RNF2 ring finger protein 2
U: 1
RNF207 ring finger protein 207
U: 1
RNF24 ring finger protein 24
D: 2
RNF7 ring finger protein 7
U: 1
D: 1
RORA RAR-related orphan receptor alpha
U: 3
RTL3 retrotransposon Gag like 3
D: 1
RXRA retinoid X receptor alpha
U: 1
D: 1
RECQL4 RecQ protein-like 4
D: 3
S100A13 S100 calcium binding protein A13
U: 2
S100A3 S100 calcium binding protein A3
D: 2
S100A6 S100 calcium binding protein A6 (calcyclin)
D: 2
S100A8 S100 calcium binding protein A8 (calgranulin A)
U: 1
S100A9 S100 calcium binding protein A9 (calgranulin B)
U: 1
D: 1
S100B S100 protein, beta polypeptide, neural
SAMHD1 SAM domain and HD domain, 1
U: 1
SCAPER S-phase cyclin A associated protein in the ER
U: 1
SEC23B SEC23 homolog B, COPII coat complex component
D: 1
SEC24B Sec24 related gene family, member B (S. cerevisiae)
U: 1
SEC24D Sec24 related gene family, member D (S. cerevisiae)
D: 2
SETDB1 SET domain, bifurcated 1
D: 1
SETMAR SET domain without mariner transposase fusion
D: 1
SF3A2 splicing factor 3a subunit 2
D: 1
SHANK3 SH3 and multiple ankyrin repeat domains 3
U: 2
SHMT1 serine hydroxymethyltransferase 1 (soluble)
U: 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
D: 1
SIAH2 siah E3 ubiquitin protein ligase 2
D: 1
SIRT2 sirtuin 2
U: 1
D: 4
SIRT3 sirtuin 3
D: 7
SIRT4 sirtuin 4
U: 2
D: 1
SIRT5 sirtuin 5
D: 1
SIRT6 sirtuin 6
D: 13
SLFN13 schlafen family member 13
D: 1
SLU7 SLU7 splicing factor homolog (S. cerevisiae)
U: 1
SMAD3 SMAD family member 3
U: 5
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
U: 1
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
U: 2
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
U: 1
SOD1 superoxide dismutase 1, soluble
U: 1
D: 3
SORD sorbitol dehydrogenase
D: 1
SPG7 SPG7, paraplegin matrix AAA peptidase subunit
U: 2
SQSTM1 sequestosome 1
U: 2
SUV39H1 suppressor of variegation 3-9 1
U: 1
D: 4
SIVA1 SIVA1, apoptosis-inducing factor
D: 1
SYTL3 synaptotagmin-like 3
U: 1
SYTL4 synaptotagmin-like 4
U: 2
TADA2B transcriptional adaptor 2B
U: 1
TCEA1 transcription elongation factor A (SII) 1
U: 1
D: 1
TCEA2 transcription elongation factor A (SII), 2
U: 2
TES testis derived transcript
D: 1
TET1 tet methylcytosine dioxygenase 1
D: 2
TET2 tet methylcytosine dioxygenase 2
D: 1
THAP1 THAP domain containing, apoptosis associated protein 1
D: 1
THAP11 THAP domain containing 11
D: 1
THRB thyroid hormone receptor beta
U: 2
D: 1
TIMM10 translocase of inner mitochondrial membrane 10
D: 1
TIMP1 tissue inhibitor of metalloproteinase 1
U: 1
D: 1
TIMP2 tissue inhibitor of metalloproteinase 2
U: 2
TK1 thymidine kinase 1
U: 1
D: 3
TLL2 tolloid-like 2
U: 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
U: 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
U: 3
TP53 tumor protein p53
U: 176
D: 8
TRAF1 TNF receptor-associated factor 1
U: 1
TRAF3 TNF receptor-associated factor 3
U: 1
TRAF5 TNF receptor-associated factor 5
U: 1
D: 1
TRHDE TRH-degrading enzyme
U: 1
TRIM14 tripartite motif-containing 14
D: 1
TRIM16 tripartite motif-containing 16
U: 1
D: 1
TRIM17 tripartite motif-containing 17
U: 1
TRIM2 tripartite motif-containing 2
D: 1
TRIM22 tripartite motif containing 22
U: 2
TRIM23 tripartite motif-containing 23
U: 1
TRIM24 tripartite motif-containing 24
D: 1
TRIM27 tripartite motif-containing 27
D: 1
TRIM28 tripartite motif-containing 28
U: 1
TRIM29 tripartite motif-containing 29
U: 3
TRIM35 tripartite motif-containing 35
U: 1
TRIM36 tripartite motif-containing 36
U: 1
D: 1
TRIM44 tripartite motif-containing 44
D: 1
TRIM45 tripartite motif-containing 45
U: 3
TRIM46 tripartite motif-containing 46
U: 1
TRIM47 tripartite motif-containing 47
D: 1
TRIM52 tripartite motif containing 52
U: 1
TRIM54 tripartite motif-containing 54
U: 1
TRIM56 tripartite motif-containing 56
U: 1
TRIM62 tripartite motif-containing 62
U: 1
TRIM65 tripartite motif-containing 65
U: 1
TRIM66 tripartite motif-containing 66
U: 1
TRIM7 tripartite motif-containing 7
U: 1
TRIM8 tripartite motif-containing 8
U: 1
TRIM9 tripartite motif-containing 9
U: 1
TRIT1 tRNA isopentenyltransferase 1
U: 1
TRPS1 transcriptional repressor GATA binding 1
D: 1
TRAFD1 TRAF type zinc finger domain containing 1
U: 1
UBR3 ubiquitin protein ligase E3 component n-recognin 3
U: 2
UHRF1 ubiquitin-like, containing PHD and RING finger domains, 1
D: 4
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
D: 1
USP16 ubiquitin specific peptidase 16
U: 1
D: 2
USP22 ubiquitin specific peptidase 22
D: 1
USP49 ubiquitin specific peptidase 49
U: 2
USP51 ubiquitin specific protease 51
U: 1
UTRN utrophin
D: 1
VAT1L vesicle amine transport protein 1 like
D: 1
WBP4 WW domain binding protein 4
D: 1
WT1 Wilms tumor 1 homolog
D: 1
XAF1 XIAP associated factor 1
U: 2
YY1 YY1 transcription factor
D: 1
ZCCHC2 zinc finger, CCHC domain containing 2
U: 1
ZCCHC24 zinc finger, CCHC domain containing 24
U: 1
ZCCHC9 zinc finger, CCHC domain containing 9
D: 1
ZCRB1 zinc finger CCHC-type and RNA binding motif 1
D: 1
ZCWPW1 zinc finger, CW type with PWWP domain 1
U: 2
ZEB1 zinc finger E-box binding homeobox 1
D: 3
ZFAND1 zinc finger, AN1-type domain 1
D: 1
ZFAND2A zinc finger, AN1-type domain 2A
U: 1
D: 2
ZFAND2B zinc finger, AN1 type domain 2B
D: 1
ZFAND3 zinc finger, AN1-type domain 3
D: 1
ZFHX3 zinc finger homeobox 3
U: 1
ZFHX4 zinc finger homeodomain 4
D: 1
ZFPL1 zinc finger protein like 1
D: 1
ZFR zinc finger RNA binding protein
U: 1
D: 1
ZGRF1 zinc finger, GRF-type containing 1
D: 1
ZMAT3 zinc finger matrin type 3
U: 2
D: 1
ZMIZ1 zinc finger, MIZ-type containing 1
U: 1
ZMYM1 zinc finger MYM-type containing 1
D: 1
ZMYM3 zinc finger, MYM-type 3
U: 1
ZMYM4 zinc finger, MYM-type 4
D: 1
ZMYM6 zinc finger MYM-type containing 6
U: 1
ZMYND11 zinc finger, MYND domain containing 11
D: 1
ZNF146 zinc finger protein 146
D: 1
ZNF184 zinc finger protein 184
D: 2
ZNF195 zinc finger protein 195
U: 1
ZNF2 zinc finger protein 2
U: 1
ZNF207 zinc finger protein 207
D: 1
ZNF214 zinc finger protein 214
D: 1
ZNF22 zinc finger protein 22
D: 2
ZNF3 zinc finger protein 3
D: 1
ZNF330 zinc finger protein 330
D: 1
ZNF331 zinc finger protein 331
U: 1
ZNF385B zinc finger protein 385B
U: 2
ZNF385C zinc finger protein 385C
D: 1
ZNF407 zinc finger protein 407
D: 1
ZNF593 zinc finger protein 593
D: 2
ZNF75D zinc finger protein 75D
U: 1
ZNF8 zinc finger protein 8
D: 1
ZNF830 zinc finger protein 830
D: 1
ZNF84 zinc finger protein 84
U: 1
ZNF90 zinc finger protein 90
U: 1
ZNF91 zinc finger protein 91
U: 1
ZNF93 zinc finger protein 93
D: 1
ZNFX1 zinc finger, NFX1-type containing 1
U: 2
ZPR1 ZPR1 zinc finger
D: 3
ZSWIM8 zinc finger SWIM-type containing 8
U: 1
ZZEF1 zinc finger, ZZ-type with EF hand domain 1
U: 1