BCL11A

BAF chromatin remodeling complex subunit BCL11A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
regulation of transcription, DNA-templated [GO:0006355],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
positive regulation of neuron projection development [GO:0010976],
negative regulation of neuron projection development [GO:0010977],
protein sumoylation [GO:0016925],
B cell differentiation [GO:0030183],
T cell differentiation [GO:0030217],
negative regulation of collateral sprouting [GO:0048671],
positive regulation of collateral sprouting [GO:0048672],
regulation of dendrite development [GO:0050773],
negative regulation of dendrite extension [GO:1903860],
negative regulation of neuron remodeling [GO:1904800],
negative regulation of dendrite development [GO:2000171],
negative regulation of branching morphogenesis of a nerve [GO:2000173],
cellular response to L-glutamate [GO:1905232],

Molecular Function:
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
nucleic acid binding [GO:0003676],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
transcription corepressor activity [GO:0003714],
protein binding [GO:0005515],
protein kinase binding [GO:0019901],
sequence-specific DNA binding [GO:0043565],
metal ion binding [GO:0046872],
protein heterodimerization activity [GO:0046982],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
postsynaptic density [GO:0014069],
nuclear body [GO:0016604],