BCL10

BCL10 immune signaling adaptor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
B cell apoptotic process [GO:0001783],
neural tube closure [GO:0001843],
stimulatory C-type lectin receptor signaling pathway [GO:0002223],
toll-like receptor signaling pathway [GO:0002224],
response to molecule of bacterial origin [GO:0002237],
adaptive immune response [GO:0002250],
negative regulation of mature B cell apoptotic process [GO:0002906],
cellular defense response [GO:0006968],
I-kappaB kinase/NF-kappaB signaling [GO:0007249],
cell death [GO:0008219],
response to fungus [GO:0009620],
immunoglobulin mediated immune response [GO:0016064],
protein ubiquitination [GO:0016567],
positive regulation of protein ubiquitination [GO:0031398],
lipopolysaccharide-mediated signaling pathway [GO:0031663],
response to food [GO:0032094],
positive regulation of mast cell cytokine production [GO:0032765],
positive regulation of kinase activity [GO:0033674],
Fc-epsilon receptor signaling pathway [GO:0038095],
lymphotoxin A biosynthetic process [GO:0042109],
interleukin-6 biosynthetic process [GO:0042226],
positive regulation of phosphorylation [GO:0042327],
positive regulation of apoptotic process [GO:0043065],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280],
innate immune response [GO:0045087],
positive regulation of interleukin-8 biosynthetic process [GO:0045416],
positive regulation of transcription, DNA-templated [GO:0045893],
T cell receptor signaling pathway [GO:0050852],
regulation of T cell receptor signaling pathway [GO:0050856],
positive regulation of T cell activation [GO:0050870],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
protein oligomerization [GO:0051259],
protein homooligomerization [GO:0051260],
protein heterooligomerization [GO:0051291],
T cell apoptotic process [GO:0070231],
cellular response to mechanical stimulus [GO:0071260],
positive regulation of extrinsic apoptotic signaling pathway [GO:2001238],
immune system process [GO:0002376],
apoptotic process [GO:0006915],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
activation of JUN kinase activity [GO:0007257],
regulation of apoptotic process [GO:0042981],
fibroblast apoptotic process [GO:0044346],
mast cell activation [GO:0045576],
thymocyte apoptotic process [GO:0070242],
positive regulation of execution phase of apoptosis [GO:1900119],

Molecular Function:
protease binding [GO:0002020],
transcription coactivator activity [GO:0003713],
protein binding [GO:0005515],
protein C-terminus binding [GO:0008022],
transcription factor binding [GO:0008134],
kinase activator activity [GO:0019209],
enzyme binding [GO:0019899],
kinase binding [GO:0019900],
protein kinase binding [GO:0019901],
ubiquitin protein ligase binding [GO:0031625],
identical protein binding [GO:0042802],
protein kinase B binding [GO:0043422],
protein self-association [GO:0043621],
CARD domain binding [GO:0050700],
NF-kappaB binding [GO:0051059],
cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656],
protein homodimerization activity [GO:0042803],
protein heterodimerization activity [GO:0046982],

Cellular Component:
immunological synapse [GO:0001772],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
lysosome [GO:0005764],
cytosol [GO:0005829],
cytoplasmic microtubule [GO:0005881],
CBM complex [GO:0032449],
macromolecular complex [GO:0032991],
membrane raft [GO:0045121],
perinuclear region of cytoplasm [GO:0048471],
membrane [GO:0016020],