BBC3

BCL2 binding component 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21678067 CCCL-1 Human NO
23665218 MEF Thymus, Spleen Mouse NO
29548335 Saos-2 Human YES

GO terms:

Biological Process:
release of cytochrome c from mitochondria [GO:0001836],
apoptotic process [GO:0006915],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
positive regulation of apoptotic process [GO:0043065],
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059],
positive regulation of release of cytochrome c from mitochondria [GO:0090200],
execution phase of apoptosis [GO:0097194],
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740],
positive regulation of cysteine-type endopeptidase activity [GO:2001056],
positive regulation of intrinsic apoptotic signaling pathway [GO:2001244],
cellular response to DNA damage stimulus [GO:0006974],
determination of adult lifespan [GO:0008340],
negative regulation of cell growth [GO:0030308],
positive regulation of protein homooligomerization [GO:0032464],
negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471],
response to endoplasmic reticulum stress [GO:0034976],
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771],
positive regulation of neuron apoptotic process [GO:0043525],
negative regulation of growth [GO:0045926],
release of sequestered calcium ion into cytosol [GO:0051209],
positive regulation of thymocyte apoptotic process [GO:0070245],
cellular response to ionizing radiation [GO:0071479],
intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332],
apoptotic signaling pathway [GO:0097190],
intrinsic apoptotic signaling pathway [GO:0097193],
toxin transport [GO:1901998],

Molecular Function:
protein binding [GO:0005515],
ATPase binding [GO:0051117],

Cellular Component:
mitochondrion [GO:0005739],
lysosome [GO:0005764],
mitochondrial envelope [GO:0005740],