BAX

BCL2 associated X, apoptosis regulator

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21678067 C-85 Human NO
23984931 HMCs Human NO

GO terms:

Biological Process:
ovarian follicle development [GO:0001541],
neuron migration [GO:0001764],
T cell homeostatic proliferation [GO:0001777],
B cell homeostasis [GO:0001782],
B cell apoptotic process [GO:0001783],
kidney development [GO:0001822],
release of cytochrome c from mitochondria [GO:0001836],
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:0001844],
blood vessel remodeling [GO:0001974],
myeloid cell homeostasis [GO:0002262],
B cell negative selection [GO:0002352],
B cell homeostatic proliferation [GO:0002358],
positive regulation of B cell apoptotic process [GO:0002904],
transcription initiation from RNA polymerase II promoter [GO:0006367],
glycosphingolipid metabolic process [GO:0006687],
regulation of nitrogen utilization [GO:0006808],
apoptotic process [GO:0006915],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977],
germ cell development [GO:0007281],
mitochondrial fusion [GO:0008053],
extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625],
intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630],
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635],
apoptotic mitochondrial changes [GO:0008637],
fertilization [GO:0009566],
response to toxic substance [GO:0009636],
response to salt stress [GO:0009651],
establishment or maintenance of transmembrane electrochemical gradient [GO:0010248],
response to gamma radiation [GO:0010332],
negative regulation of mitochondrial membrane potential [GO:0010917],
viral process [GO:0016032],
hypothalamus development [GO:0021854],
cerebral cortex development [GO:0021987],
negative regulation of protein binding [GO:0032091],
positive regulation of protein oligomerization [GO:0032461],
endoplasmic reticulum calcium ion homeostasis [GO:0032469],
negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471],
release of matrix enzymes from mitochondria [GO:0032976],
negative regulation of peptidyl-serine phosphorylation [GO:0033137],
regulation of mammary gland epithelial cell proliferation [GO:0033599],
cellular response to unfolded protein [GO:0034620],
cellular response to UV [GO:0034644],
ectopic germ cell programmed cell death [GO:0035234],
odontogenesis of dentin-containing tooth [GO:0042475],
regulation of apoptotic process [GO:0042981],
positive regulation of apoptotic process [GO:0043065],
regulation of protein homodimerization activity [GO:0043496],
regulation of protein heterodimerization activity [GO:0043497],
negative regulation of neuron apoptotic process [GO:0043524],
positive regulation of neuron apoptotic process [GO:0043525],
mitochondrial fragmentation involved in apoptotic process [GO:0043653],
development of secondary sexual characteristics [GO:0045136],
retinal cell programmed cell death [GO:0046666],
positive regulation of developmental pigmentation [GO:0048087],
negative regulation of fibroblast proliferation [GO:0048147],
spermatid differentiation [GO:0048515],
post-embryonic camera-type eye morphogenesis [GO:0048597],
response to axon injury [GO:0048678],
homeostasis of number of cells within a tissue [GO:0048873],
protein oligomerization [GO:0051259],
protein homooligomerization [GO:0051260],
positive regulation of release of sequestered calcium ion into cytosol [GO:0051281],
neuron apoptotic process [GO:0051402],
regulation of mitochondrial membrane potential [GO:0051881],
Sertoli cell proliferation [GO:0060011],
retina development in camera-type eye [GO:0060041],
positive regulation of apoptotic process involved in mammary gland involution [GO:0060058],
vagina development [GO:0060068],
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059],
thymocyte apoptotic process [GO:0070242],
mitochondrion morphogenesis [GO:0070584],
intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332],
positive regulation of release of cytochrome c from mitochondria [GO:0090200],
apoptotic signaling pathway [GO:0097190],
extrinsic apoptotic signaling pathway [GO:0097191],
extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192],
intrinsic apoptotic signaling pathway [GO:0097193],
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097296],
positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103],
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030],
apoptotic process involved in patterning of blood vessels [GO:1902262],
apoptotic process involved in embryonic digit morphogenesis [GO:1902263],
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [GO:1902445],
positive regulation of apoptotic DNA fragmentation [GO:1902512],
positive regulation of IRE1-mediated unfolded protein response [GO:1903896],
B cell receptor apoptotic signaling pathway [GO:1990117],
negative regulation of apoptotic signaling pathway [GO:2001234],
positive regulation of intrinsic apoptotic signaling pathway [GO:2001244],
leukocyte homeostasis [GO:0001776],
cellular response to DNA damage stimulus [GO:0006974],
inner mitochondrial membrane organization [GO:0007007],
outer mitochondrial membrane organization [GO:0007008],
spermatogenesis [GO:0007283],
nervous system development [GO:0007399],
sex differentiation [GO:0007548],
cell proliferation [GO:0008283],
negative regulation of cell proliferation [GO:0008285],
male gonad development [GO:0008584],
response to wounding [GO:0009611],
post-embryonic development [GO:0009791],
response to ionizing radiation [GO:0010212],
positive regulation of calcium ion transport into cytosol [GO:0010524],
limb morphogenesis [GO:0035108],
regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281],
regulation of neuron apoptotic process [GO:0043523],
cellular respiration [GO:0045333],
homeostasis of number of cells [GO:0048872],
regulation of cell cycle [GO:0051726],
cellular response to organic substance [GO:0071310],
regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108],
positive regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902110],
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241],

Molecular Function:
protein binding [GO:0005515],
lipid binding [GO:0008289],
channel activity [GO:0015267],
Hsp70 protein binding [GO:0030544],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
protein heterodimerization activity [GO:0046982],
chaperone binding [GO:0051087],
BH3 domain binding [GO:0051434],
heat shock protein binding [GO:0031072],
macromolecular complex binding [GO:0044877],
BH domain binding [GO:0051400],

Cellular Component:
nucleus [GO:0005634],
nuclear envelope [GO:0005635],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
mitochondrial outer membrane [GO:0005741],
mitochondrial permeability transition pore complex [GO:0005757],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
cytosol [GO:0005829],
membrane [GO:0016020],
pore complex [GO:0046930],
extracellular exosome [GO:0070062],
cell periphery [GO:0071944],
Bcl-2 family protein complex [GO:0097136],
BAX complex [GO:0097144],
integral component of membrane [GO:0016021],
mitochondrial membrane [GO:0031966],
perinuclear region of cytoplasm [GO:0048471],