AXL

AXL receptor tyrosine kinase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
25766527 VSMCs Aorta Mouse NO
27206970 VSMCs, MOVAS Aorta Mouse NO
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
neuron migration [GO:0001764],
natural killer cell differentiation [GO:0001779],
positive regulation of cytokine-mediated signaling pathway [GO:0001961],
blood vessel remodeling [GO:0001974],
phagocytosis [GO:0006909],
inflammatory response [GO:0006954],
signal transduction [GO:0007165],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
spermatogenesis [GO:0007283],
nervous system development [GO:0007399],
Wnt signaling pathway [GO:0016055],
cell migration [GO:0016477],
peptidyl-tyrosine phosphorylation [GO:0018108],
forebrain cell migration [GO:0021885],
platelet activation [GO:0030168],
animal organ regeneration [GO:0031100],
cellular response to extracellular stimulus [GO:0031668],
negative regulation of interferon-gamma production [GO:0032689],
negative regulation of tumor necrosis factor production [GO:0032720],
positive regulation of natural killer cell differentiation [GO:0032825],
secretion by cell [GO:0032940],
erythrocyte homeostasis [GO:0034101],
substrate adhesion-dependent cell spreading [GO:0034446],
cellular response to interferon-alpha [GO:0035457],
ovulation cycle [GO:0042698],
negative regulation of apoptotic process [GO:0043066],
apoptotic cell clearance [GO:0043277],
protein kinase B signaling [GO:0043491],
negative regulation of neuron apoptotic process [GO:0043524],
innate immune response [GO:0045087],
viral entry into host cell [GO:0046718],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
cell maturation [GO:0048469],
positive regulation of pinocytosis [GO:0048549],
negative regulation of lymphocyte activation [GO:0051250],
positive regulation of protein kinase B signaling [GO:0051897],
vagina development [GO:0060068],
cellular response to hydrogen peroxide [GO:0070301],
cellular response to lipopolysaccharide [GO:0071222],
dendritic cell differentiation [GO:0097028],
neutrophil clearance [GO:0097350],
negative regulation of dendritic cell apoptotic process [GO:2000669],
negative regulation of cytokine production [GO:0001818],
immune system process [GO:0002376],
protein phosphorylation [GO:0006468],
enzyme linked receptor protein signaling pathway [GO:0007167],
phosphorylation [GO:0016310],
cell differentiation [GO:0030154],

Molecular Function:
virus receptor activity [GO:0001618],
phosphatidylserine binding [GO:0001786],
protein tyrosine kinase activity [GO:0004713],
transmembrane receptor protein tyrosine kinase activity [GO:0004714],
protein binding [GO:0005515],
ATP binding [GO:0005524],
Wnt-protein binding [GO:0017147],
myosin heavy chain binding [GO:0032036],
phosphatidylinositol 3-kinase binding [GO:0043548],
protein heterodimerization activity [GO:0046982],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
extracellular space [GO:0005615],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell surface [GO:0009986],
receptor complex [GO:0043235],
host cell surface [GO:0044228],
extracellular exosome [GO:0070062],
membrane [GO:0016020],
integral component of membrane [GO:0016021],