AURKA

aurora kinase A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
20382844 RPMI8226, OPM1, primary plasma cells derived from bone marrow Human NO
22274399 Primary glia derived from brain Brain Human NO
23180582 Hs294T, SK-Mel-2, SK-Mel-5, SK-Mel-28 cells Melanoma implants from patients Human NO
24901229 GIST882, GIST48, GIST43 Gastrointestinal tract Human NO
24989836 DU-145, LNCaP, PC3 Prostate Human NO
25736378 Mammary gland Mouse NO
27713168 A549, A427, NCI-H1299 Human NO
27824120 U937, HL-6, Jurkat, K562, NB4, KBM5, KBM5-T315I, 32D, Primary cells derived from bone marrow Human, mouse NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2 Human YES
30987592 MCF7 Breast Human YES
 23324396 hTERT RPE-1 Human NO

GO terms:

Biological Process:
G2/M transition of mitotic cell cycle [GO:0000086],
mitotic cell cycle [GO:0000278],
protein phosphorylation [GO:0006468],
ubiquitin-dependent protein catabolic process [GO:0006511],
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977],
spindle organization [GO:0007051],
mitotic spindle organization [GO:0007052],
spindle assembly involved in female meiosis I [GO:0007057],
mitotic centrosome separation [GO:0007100],
response to wounding [GO:0009611],
anterior/posterior axis specification [GO:0009948],
regulation of G2/M transition of mitotic cell cycle [GO:0010389],
negative regulation of G2/M transition of mitotic cell cycle [GO:0010972],
anaphase-promoting complex-dependent catabolic process [GO:0031145],
regulation of protein stability [GO:0031647],
negative regulation of protein binding [GO:0032091],
positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436],
regulation of cytokinesis [GO:0032465],
histone-serine phosphorylation [GO:0035404],
negative regulation of apoptotic process [GO:0043066],
positive regulation of mitotic nuclear division [GO:0045840],
regulation of centrosome cycle [GO:0046605],
protein autophosphorylation [GO:0046777],
cell division [GO:0051301],
centrosome localization [GO:0051642],
protein localization to centrosome [GO:0071539],
liver regeneration [GO:0097421],
positive regulation of oocyte maturation [GO:1900195],
regulation of signal transduction by p53 class mediator [GO:1901796],
neuron projection extension [GO:1990138],
meiotic spindle organization [GO:0000212],
microtubule cytoskeleton organization [GO:0000226],
cell cycle [GO:0007049],
centrosome cycle [GO:0007098],
phosphorylation [GO:0016310],
cell projection organization [GO:0030030],
meiotic cell cycle [GO:0051321],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
protein serine/threonine/tyrosine kinase activity [GO:0004712],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein kinase binding [GO:0019901],
ubiquitin protein ligase binding [GO:0031625],
histone serine kinase activity [GO:0035174],
protein heterodimerization activity [GO:0046982],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
condensed nuclear chromosome, centromeric region [GO:0000780],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
centrosome [GO:0005813],
centriole [GO:0005814],
spindle [GO:0005819],
cytosol [GO:0005829],
spindle microtubule [GO:0005876],
cilium [GO:0005929],
microtubule cytoskeleton [GO:0015630],
midbody [GO:0030496],
spindle pole centrosome [GO:0031616],
chromosome passenger complex [GO:0032133],
germinal vesicle [GO:0042585],
axon hillock [GO:0043203],
pronucleus [GO:0045120],
perinuclear region of cytoplasm [GO:0048471],
spindle midzone [GO:0051233],
meiotic spindle [GO:0072687],
mitotic spindle pole [GO:0097431],
cytoplasm [GO:0005737],
microtubule organizing center [GO:0005815],
cytoskeleton [GO:0005856],
microtubule [GO:0005874],
cell projection [GO:0042995],
mitotic spindle [GO:0072686],