PPARGC1A

PPARG coactivator 1 alpha

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
23159434 Ear Rat NO
23430617 Primary cells derived from aortic smooth muscle Aorta Rodents NO
27381955 HASMC Human NO
28963101 Aorta Mouse NO
30087287 Primary cells derived from PRE Human, mouse NO

GO terms:

Biological Process:
response to reactive oxygen species [GO:0000302],
mitophagy [GO:0000422],
temperature homeostasis [GO:0001659],
cellular glucose homeostasis [GO:0001678],
negative regulation of protein phosphorylation [GO:0001933],
response to dietary excess [GO:0002021],
response to ischemia [GO:0002931],
galactose metabolic process [GO:0006012],
gluconeogenesis [GO:0006094],
regulation of transcription, DNA-templated [GO:0006355],
transcription initiation from RNA polymerase II promoter [GO:0006367],
mRNA processing [GO:0006397],
mitochondrion organization [GO:0007005],
aging [GO:0007568],
digestion [GO:0007586],
circadian rhythm [GO:0007623],
androgen metabolic process [GO:0008209],
RNA splicing [GO:0008380],
response to cold [GO:0009409],
positive regulation of gene expression [GO:0010628],
positive regulation of mitochondrion organization [GO:0010822],
skeletal muscle atrophy [GO:0014732],
response to muscle activity [GO:0014850],
response to electrical stimulus involved in regulation of muscle adaptation [GO:0014878],
negative regulation of smooth muscle cell migration [GO:0014912],
fatty acid oxidation [GO:0019395],
cerebellum development [GO:0021549],
respiratory electron transport chain [GO:0022904],
androgen receptor signaling pathway [GO:0030521],
forebrain development [GO:0030900],
circadian regulation of gene expression [GO:0032922],
cellular response to oxidative stress [GO:0034599],
positive regulation of histone acetylation [GO:0035066],
cellular response to potassium ion [GO:0035865],
response to starvation [GO:0042594],
regulation of circadian rhythm [GO:0042752],
response to leucine [GO:0043201],
negative regulation of neuron apoptotic process [GO:0043524],
cellular respiration [GO:0045333],
positive regulation of gluconeogenesis [GO:0045722],
negative regulation of glycolytic process [GO:0045820],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of fatty acid oxidation [GO:0046321],
positive regulation of smooth muscle cell proliferation [GO:0048661],
negative regulation of smooth muscle cell proliferation [GO:0048662],
protein stabilization [GO:0050821],
brown fat cell differentiation [GO:0050873],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
flavone metabolic process [GO:0051552],
adipose tissue development [GO:0060612],
macromolecular complex assembly [GO:0065003],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to nitrite [GO:0071250],
cellular response to caffeine [GO:0071313],
cellular response to fructose stimulus [GO:0071332],
cellular response to glucose stimulus [GO:0071333],
cellular response to interleukin-6 [GO:0071354],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to follicle-stimulating hormone stimulus [GO:0071372],
cellular response to estradiol stimulus [GO:0071392],
cellular response to hypoxia [GO:0071456],
cellular response to transforming growth factor beta stimulus [GO:0071560],
response to epinephrine [GO:0071871],
response to norepinephrine [GO:0071873],
negative regulation of mitochondrial fission [GO:0090258],
energy homeostasis [GO:0097009],
cellular response to thyroid hormone stimulus [GO:0097067],
negative regulation of neuron death [GO:1901215],
response to metformin [GO:1901558],
positive regulation of cellular respiration [GO:1901857],
positive regulation of mitochondrial DNA metabolic process [GO:1901860],
positive regulation of muscle tissue development [GO:1901863],
positive regulation of glomerular visceral epithelial cell apoptotic process [GO:1904635],
cellular response to ionomycin [GO:1904637],
cellular response to resveratrol [GO:1904639],
response to methionine [GO:1904640],
adaptive thermogenesis [GO:1990845],
positive regulation of progesterone biosynthetic process [GO:2000184],
negative regulation of receptor activity [GO:2000272],
regulation of N-methyl-D-aspartate selective glutamate receptor activity [GO:2000310],
positive regulation of ATP biosynthetic process [GO:2001171],
response to activity [GO:0014823],
positive regulation of cellular metabolic process [GO:0031325],
rhythmic process [GO:0048511],

Molecular Function:
DNA binding [GO:0003677],
transcription cofactor activity [GO:0003712],
transcription coactivator activity [GO:0003713],
RNA binding [GO:0003723],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
ligand-dependent nuclear receptor binding [GO:0016922],
estrogen receptor binding [GO:0030331],
ligand-dependent nuclear receptor transcription coactivator activity [GO:0030374],
chromatin DNA binding [GO:0031490],
ubiquitin protein ligase binding [GO:0031625],
peroxisome proliferator activated receptor binding [GO:0042975],
alpha-tubulin binding [GO:0043014],
sequence-specific DNA binding [GO:0043565],
androgen receptor binding [GO:0050681],
promoter-specific chromatin binding [GO:1990841],
nucleic acid binding [GO:0003676],
chromatin binding [GO:0003682],
receptor binding [GO:0005102],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nuclear euchromatin [GO:0005719],
PML body [GO:0016605],
cytosolic ribosome [GO:0022626],
neuronal cell body [GO:0043025],
intracellular membrane-bounded organelle [GO:0043231],
apical dendrite [GO:0097440],
subsarcolemmal mitochondrion [GO:1990843],
interfibrillar mitochondrion [GO:1990844],
cytoplasm [GO:0005737],
cytosol [GO:0005829],