PPARG

peroxisome proliferator activated receptor gamma

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
18544633 2BS Human NO
20660480 2BS, WI-38 Skin Human, mouse NO
30987592 MCF7 Breast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
25101957 HDF Human NO
28514051 IMR-90 Human NO
29735632 Carotid arteries Mouse NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
placenta development [GO:0001890],
negative regulation of acute inflammatory response [GO:0002674],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
transcription initiation from RNA polymerase II promoter [GO:0006367],
lipid metabolic process [GO:0006629],
fatty acid metabolic process [GO:0006631],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
signal transduction [GO:0007165],
G-protein coupled receptor signaling pathway [GO:0007186],
multicellular organism development [GO:0007275],
heart development [GO:0007507],
response to nutrient [GO:0007584],
regulation of blood pressure [GO:0008217],
response to cold [GO:0009409],
response to mechanical stimulus [GO:0009612],
hormone-mediated signaling pathway [GO:0009755],
macrophage derived foam cell differentiation [GO:0010742],
negative regulation of macrophage derived foam cell differentiation [GO:0010745],
negative regulation of receptor biosynthetic process [GO:0010871],
negative regulation of cholesterol storage [GO:0010887],
negative regulation of sequestering of triglyceride [GO:0010891],
long-chain fatty acid transport [GO:0015909],
negative regulation of angiogenesis [GO:0016525],
regulation of lipid metabolic process [GO:0019216],
fatty acid oxidation [GO:0019395],
cell differentiation [GO:0030154],
monocyte differentiation [GO:0030224],
negative regulation of cell growth [GO:0030308],
epithelial cell differentiation [GO:0030855],
response to caffeine [GO:0031000],
animal organ regeneration [GO:0031100],
response to retinoic acid [GO:0032526],
cellular response to insulin stimulus [GO:0032869],
negative regulation of collagen biosynthetic process [GO:0032966],
response to vitamin A [GO:0033189],
response to lipid [GO:0033993],
peroxisome proliferator activated receptor signaling pathway [GO:0035357],
response to immobilization stress [GO:0035902],
glucose homeostasis [GO:0042593],
response to starvation [GO:0042594],
regulation of circadian rhythm [GO:0042752],
lipoprotein transport [GO:0042953],
positive regulation of DNA binding [GO:0043388],
steroid hormone mediated signaling pathway [GO:0043401],
negative regulation of blood vessel endothelial cell migration [GO:0043537],
response to estrogen [GO:0043627],
innate immune response [GO:0045087],
cell fate commitment [GO:0045165],
positive regulation of fat cell differentiation [GO:0045600],
low-density lipoprotein particle receptor biosynthetic process [GO:0045713],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of fatty acid oxidation [GO:0046321],
cell maturation [GO:0048469],
rhythmic process [GO:0048511],
negative regulation of smooth muscle cell proliferation [GO:0048662],
positive regulation of oligodendrocyte differentiation [GO:0048714],
white fat cell differentiation [GO:0050872],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
negative regulation of telomerase activity [GO:0051974],
lipid homeostasis [GO:0055088],
positive regulation of phagocytosis, engulfment [GO:0060100],
negative regulation of interferon-gamma-mediated signaling pathway [GO:0060336],
regulation of cholesterol transporter activity [GO:0060694],
regulation of transcription involved in cell fate commitment [GO:0060850],
negative regulation of gene silencing by miRNA [GO:0060965],
pri-miRNA transcription from RNA polymerase II promoter [GO:0061614],
cellular response to retinoic acid [GO:0071300],
cellular response to vitamin E [GO:0071306],
cellular response to prostaglandin E stimulus [GO:0071380],
cellular response to low-density lipoprotein particle stimulus [GO:0071404],
cellular response to hyperoxia [GO:0071455],
response to metformin [GO:1901558],
negative regulation of vascular smooth muscle cell proliferation [GO:1904706],
positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461],
negative regulation of vascular endothelial cell proliferation [GO:1905563],
negative regulation of pancreatic stellate cell proliferation [GO:2000230],
negative regulation of cytokine production [GO:0001818],
response to dietary excess [GO:0002021],
diet induced thermogenesis [GO:0002024],
regulation of transcription, DNA-templated [GO:0006355],
inflammatory response [GO:0006954],
negative regulation of cell proliferation [GO:0008285],
response to light stimulus [GO:0009416],
regulation of gene expression [GO:0010468],
response to food [GO:0032094],
positive regulation of apoptotic process [GO:0043065],
fat cell differentiation [GO:0045444],
regulation of fat cell differentiation [GO:0045598],
brown fat cell differentiation [GO:0050873],
cellular response to lithium ion [GO:0071285],
cellular response to organic cyclic compound [GO:0071407],
negative regulation of peptide hormone secretion [GO:0090278],
negative regulation of cellular response to insulin stimulus [GO:1900077],
negative regulation of microglial cell activation [GO:1903979],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
RNA polymerase II repressing transcription factor binding [GO:0001103],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
double-stranded DNA binding [GO:0003690],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
steroid hormone receptor activity [GO:0003707],
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding [GO:0004879],
prostaglandin receptor activity [GO:0004955],
fatty acid binding [GO:0005504],
protein binding [GO:0005515],
protein C-terminus binding [GO:0008022],
transcription factor binding [GO:0008134],
drug binding [GO:0008144],
zinc ion binding [GO:0008270],
lipid binding [GO:0008289],
enzyme binding [GO:0019899],
protein phosphatase binding [GO:0019903],
estrogen receptor binding [GO:0030331],
ligand-dependent nuclear receptor transcription coactivator activity [GO:0030374],
activating transcription factor binding [GO:0033613],
signaling receptor activity [GO:0038023],
peptide binding [GO:0042277],
identical protein binding [GO:0042802],
sequence-specific DNA binding [GO:0043565],
protein self-association [GO:0043621],
transcription regulatory region DNA binding [GO:0044212],
retinoid X receptor binding [GO:0046965],
protein heterodimerization activity [GO:0046982],
arachidonic acid binding [GO:0050544],
DBD domain binding [GO:0050692],
LBD domain binding [GO:0050693],
alpha-actinin binding [GO:0051393],
E-box binding [GO:0070888],
RNA polymerase II regulatory region DNA binding [GO:0001012],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
metal ion binding [GO:0046872],
WW domain binding [GO:0050699],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
macromolecular complex [GO:0032991],
intracellular membrane-bounded organelle [GO:0043231],
perinuclear region of cytoplasm [GO:0048471],
RNA polymerase II transcription factor complex [GO:0090575],
cytoplasm [GO:0005737],