PPARD

peroxisome proliferator activated receptor delta

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
24213576 HaCat, Primary keratinocytes Human, mouse NO
24898257 HaCat, Primary keratinocytes Intestine Human, mouse NO
25754218 Primary aortic endothelial cells Bovine NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
21352808 VSMC Human NO
22072715 VSMC Blood vessel Human NO
22335598 Primary keratinocytes Skin Human, mouse NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
glucose metabolic process [GO:0006006],
proteoglycan metabolic process [GO:0006029],
generation of precursor metabolites and energy [GO:0006091],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
transcription initiation from RNA polymerase II promoter [GO:0006367],
lipid metabolic process [GO:0006629],
fatty acid metabolic process [GO:0006631],
fatty acid beta-oxidation [GO:0006635],
vitamin A metabolic process [GO:0006776],
apoptotic process [GO:0006915],
multicellular organism development [GO:0007275],
heart development [GO:0007507],
embryo implantation [GO:0007566],
cholesterol metabolic process [GO:0008203],
cell proliferation [GO:0008283],
axon ensheathment [GO:0008366],
phospholipid biosynthetic process [GO:0008654],
fatty acid catabolic process [GO:0009062],
mRNA transcription [GO:0009299],
response to glucose [GO:0009749],
hormone-mediated signaling pathway [GO:0009755],
negative regulation of cholesterol storage [GO:0010887],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
response to activity [GO:0014823],
regulation of skeletal muscle satellite cell proliferation [GO:0014842],
negative regulation of smooth muscle cell migration [GO:0014912],
fatty acid transport [GO:0015908],
regulation of lipid metabolic process [GO:0019216],
cell differentiation [GO:0030154],
negative regulation of cell growth [GO:0030308],
intracellular receptor signaling pathway [GO:0030522],
cell-substrate adhesion [GO:0031589],
positive regulation of insulin secretion [GO:0032024],
negative regulation of collagen biosynthetic process [GO:0032966],
response to vitamin A [GO:0033189],
response to lipid [GO:0033993],
wound healing [GO:0042060],
negative regulation of apoptotic process [GO:0043066],
steroid hormone mediated signaling pathway [GO:0043401],
positive regulation of skeletal muscle tissue regeneration [GO:0043415],
keratinocyte proliferation [GO:0043616],
positive regulation of fat cell differentiation [GO:0045600],
negative regulation of myoblast differentiation [GO:0045662],
positive regulation of epidermis development [GO:0045684],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
decidualization [GO:0046697],
negative regulation of smooth muscle cell proliferation [GO:0048662],
negative regulation of epithelial cell proliferation [GO:0050680],
negative regulation of inflammatory response [GO:0050728],
keratinocyte migration [GO:0051546],
adipose tissue development [GO:0060612],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to hypoxia [GO:0071456],
apoptotic signaling pathway [GO:0097190],
negative regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902894],
glucose transmembrane transport [GO:1904659],
positive regulation of myoblast proliferation [GO:2000288],
placenta development [GO:0001890],
regulation of transcription, DNA-templated [GO:0006355],
positive regulation of cell proliferation [GO:0008284],
epidermis development [GO:0008544],
cellular process [GO:0009987],
positive regulation of gene expression [GO:0010628],
fatty acid oxidation [GO:0019395],
regulation of cell proliferation [GO:0042127],
regulation of fat cell differentiation [GO:0045598],
regulation of insulin secretion [GO:0050796],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
RNA polymerase II repressing transcription factor binding [GO:0001103],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
DNA binding [GO:0003677],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
steroid hormone receptor activity [GO:0003707],
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding [GO:0004879],
fatty acid binding [GO:0005504],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
drug binding [GO:0008144],
zinc ion binding [GO:0008270],
lipid binding [GO:0008289],
ligand-dependent nuclear receptor transcription coactivator activity [GO:0030374],
signaling receptor activity [GO:0038023],
protein heterodimerization activity [GO:0046982],
NF-kappaB binding [GO:0051059],
linoleic acid binding [GO:0070539],
transcription coactivator activity [GO:0003713],
enzyme activator activity [GO:0008047],
prostacyclin receptor activity [GO:0016501],
sequence-specific DNA binding [GO:0043565],
metal ion binding [GO:0046872],
retinoid X receptor binding [GO:0046965],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
RNA polymerase II transcription factor complex [GO:0090575],