ATP7A

ATPase copper transporting alpha

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
blood vessel development [GO:0001568],
in utero embryonic development [GO:0001701],
liver development [GO:0001889],
blood vessel remodeling [GO:0001974],
regulation of oxidative phosphorylation [GO:0002082],
tryptophan metabolic process [GO:0006568],
catecholamine metabolic process [GO:0006584],
copper ion transport [GO:0006825],
cellular copper ion homeostasis [GO:0006878],
mitochondrion organization [GO:0007005],
lactation [GO:0007595],
locomotory behavior [GO:0007626],
response to iron(III) ion [GO:0010041],
response to manganese ion [GO:0010042],
response to zinc ion [GO:0010043],
detoxification of copper ion [GO:0010273],
regulation of gene expression [GO:0010468],
positive regulation of lamellipodium assembly [GO:0010592],
copper ion import [GO:0015677],
peptidyl-lysine modification [GO:0018205],
removal of superoxide radicals [GO:0019430],
antimicrobial humoral response [GO:0019730],
cerebellar Purkinje cell differentiation [GO:0021702],
pyramidal neuron development [GO:0021860],
central nervous system neuron development [GO:0021954],
extracellular matrix organization [GO:0030198],
collagen fibril organization [GO:0030199],
hair follicle morphogenesis [GO:0031069],
ion transmembrane transport [GO:0034220],
negative regulation of iron ion transmembrane transport [GO:0034760],
cellular response to platelet-derived growth factor stimulus [GO:0036120],
T-helper cell differentiation [GO:0042093],
epinephrine metabolic process [GO:0042414],
norepinephrine metabolic process [GO:0042415],
dopamine metabolic process [GO:0042417],
serotonin metabolic process [GO:0042428],
positive regulation of catalytic activity [GO:0043085],
negative regulation of catalytic activity [GO:0043086],
pigmentation [GO:0043473],
skin development [GO:0043588],
positive regulation of cell size [GO:0045793],
elastic fiber assembly [GO:0048251],
lung alveolus development [GO:0048286],
neuron projection morphogenesis [GO:0048812],
positive regulation of epithelial cell proliferation [GO:0050679],
cartilage development [GO:0051216],
positive regulation of oxidoreductase activity [GO:0051353],
elastin biosynthetic process [GO:0051542],
copper ion export [GO:0060003],
cellular response to amino acid stimulus [GO:0071230],
cellular response to antibiotic [GO:0071236],
cellular response to cadmium ion [GO:0071276],
cellular response to cobalt ion [GO:0071279],
cellular response to copper ion [GO:0071280],
cellular response to iron ion [GO:0071281],
cellular response to lead ion [GO:0071284],
cellular response to hypoxia [GO:0071456],
positive regulation of response to wounding [GO:1903036],
positive regulation of vascular associated smooth muscle cell migration [GO:1904754],
regulation of cytochrome-c oxidase activity [GO:1904959],
release of cytochrome c from mitochondria [GO:0001836],
tyrosine metabolic process [GO:0006570],
ion transport [GO:0006811],
cation transport [GO:0006812],
metal ion transport [GO:0030001],
hindlimb morphogenesis [GO:0035137],
norepinephrine biosynthetic process [GO:0042421],
negative regulation of neuron apoptotic process [GO:0043524],
ATP metabolic process [GO:0046034],
response to copper ion [GO:0046688],
dendrite morphogenesis [GO:0048813],

Molecular Function:
copper-exporting ATPase activity [GO:0004008],
copper ion transmembrane transporter activity [GO:0005375],
copper ion binding [GO:0005507],
protein binding [GO:0005515],
ATP binding [GO:0005524],
superoxide dismutase copper chaperone activity [GO:0016532],
copper-dependent protein binding [GO:0032767],
copper-transporting ATPase activity [GO:0043682],
Rac GTPase binding [GO:0048365],
chaperone binding [GO:0051087],
cuprous ion binding [GO:1903136],
nucleotide binding [GO:0000166],
cation-transporting ATPase activity [GO:0019829],
metal ion binding [GO:0046872],

Cellular Component:
nucleus [GO:0005634],
late endosome [GO:0005770],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
trans-Golgi network [GO:0005802],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
microvillus [GO:0005902],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
trans-Golgi network transport vesicle [GO:0030140],
secretory granule [GO:0030141],
phagocytic vesicle membrane [GO:0030670],
cell leading edge [GO:0031252],
brush border membrane [GO:0031526],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
perikaryon [GO:0043204],
membrane raft [GO:0045121],
perinuclear region of cytoplasm [GO:0048471],
cytoplasmic vesicle [GO:0031410],