PIK3R1

phosphoinositide-3-kinase regulatory subunit 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
cellular glucose homeostasis [GO:0001678],
negative regulation of cell-matrix adhesion [GO:0001953],
protein phosphorylation [GO:0006468],
protein import into nucleus [GO:0006606],
phosphatidylinositol biosynthetic process [GO:0006661],
epidermal growth factor receptor signaling pathway [GO:0007173],
G-protein coupled receptor signaling pathway [GO:0007186],
axon guidance [GO:0007411],
insulin receptor signaling pathway [GO:0008286],
extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625],
intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630],
phosphatidylinositol 3-kinase signaling [GO:0014065],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
viral process [GO:0016032],
cytokine-mediated signaling pathway [GO:0019221],
platelet activation [GO:0030168],
B cell differentiation [GO:0030183],
positive regulation of cell migration [GO:0030335],
T cell costimulation [GO:0031295],
positive regulation of tumor necrosis factor production [GO:0032760],
cellular response to insulin stimulus [GO:0032869],
positive regulation of RNA splicing [GO:0033120],
cellular response to UV [GO:0034644],
response to endoplasmic reticulum stress [GO:0034976],
Fc-epsilon receptor signaling pathway [GO:0038095],
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096],
ERBB2 signaling pathway [GO:0038128],
positive regulation of protein import into nucleus [GO:0042307],
negative regulation of apoptotic process [GO:0043066],
regulation of phosphatidylinositol 3-kinase activity [GO:0043551],
negative regulation of osteoclast differentiation [GO:0045671],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of glucose import [GO:0046326],
regulation of insulin receptor signaling pathway [GO:0046626],
phosphatidylinositol phosphorylation [GO:0046854],
insulin-like growth factor receptor signaling pathway [GO:0048009],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
phosphatidylinositol-mediated signaling [GO:0048015],
protein stabilization [GO:0050821],
T cell receptor signaling pathway [GO:0050852],
leukocyte migration [GO:0050900],
regulation of stress fiber assembly [GO:0051492],
positive regulation of protein kinase B signaling [GO:0051897],
growth hormone receptor signaling pathway [GO:0060396],
positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103],
positive regulation of protein localization to plasma membrane [GO:1903078],
positive regulation of protein phosphorylation [GO:0001934],
glucose metabolic process [GO:0006006],
negative regulation of cell adhesion [GO:0007162],
signal transduction [GO:0007165],
negative regulation of heart rate [GO:0010459],
positive regulation of gene expression [GO:0010628],
negative regulation of muscle cell apoptotic process [GO:0010656],
protein transport [GO:0015031],
negative regulation of cell-cell adhesion [GO:0022408],
response to insulin [GO:0032868],
positive regulation of myoblast differentiation [GO:0045663],
negative regulation of blood pressure [GO:0045776],
negative regulation of proteolysis [GO:0045861],
negative regulation of smooth muscle cell proliferation [GO:0048662],
response to glucocorticoid [GO:0051384],
response to cAMP [GO:0051591],
regulation of protein localization to plasma membrane [GO:1903076],

Molecular Function:
phosphotyrosine binding [GO:0001784],
transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068],
insulin receptor binding [GO:0005158],
insulin-like growth factor receptor binding [GO:0005159],
neurotrophin TRKA receptor binding [GO:0005168],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
protein phosphatase binding [GO:0019903],
phosphatidylinositol 3-kinase regulator activity [GO:0035014],
phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312],
ErbB-3 class receptor binding [GO:0043125],
phosphatidylinositol 3-kinase binding [GO:0043548],
insulin binding [GO:0043559],
insulin receptor substrate binding [GO:0043560],
1-phosphatidylinositol-3-kinase regulator activity [GO:0046935],
protein heterodimerization activity [GO:0046982],
receptor binding [GO:0005102],
platelet-derived growth factor receptor binding [GO:0005161],
calmodulin binding [GO:0005516],
protein C-terminus binding [GO:0008022],
1-phosphatidylinositol-3-kinase activity [GO:0016303],
protein kinase binding [GO:0019901],
protein domain specific binding [GO:0019904],
estrogen receptor binding [GO:0030331],
receptor tyrosine kinase binding [GO:0030971],
ubiquitin protein ligase binding [GO:0031625],
ATPase binding [GO:0051117],
phosphoprotein binding [GO:0051219],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cis-Golgi network [GO:0005801],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cell-cell junction [GO:0005911],
phosphatidylinositol 3-kinase complex [GO:0005942],
phosphatidylinositol 3-kinase complex, class IA [GO:0005943],
membrane [GO:0016020],
perinuclear endoplasmic reticulum membrane [GO:1990578],
macromolecular complex [GO:0032991],
neuron projection [GO:0043005],