ATP1A3

ATPase Na+/K+ transporting subunit alpha 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

GO terms:

Biological Process:
cellular sodium ion homeostasis [GO:0006883],
establishment or maintenance of transmembrane electrochemical gradient [GO:0010248],
ATP hydrolysis coupled proton transport [GO:0015991],
cellular potassium ion homeostasis [GO:0030007],
ion transmembrane transport [GO:0034220],
sodium ion export from cell [GO:0036376],
regulation of resting membrane potential [GO:0060075],
cellular response to steroid hormone stimulus [GO:0071383],
cell communication by electrical coupling involved in cardiac conduction [GO:0086064],
regulation of presynaptic membrane potential [GO:0099505],
response to glycoside [GO:1903416],
regulation of cardiac conduction [GO:1903779],
cellular response to beta-amyloid [GO:1904646],
neuron projection maintenance [GO:1990535],
potassium ion import across plasma membrane [GO:1990573],
ion transport [GO:0006811],
potassium ion transport [GO:0006813],
sodium ion transport [GO:0006814],
memory [GO:0007613],
adult locomotory behavior [GO:0008344],
visual learning [GO:0008542],
ionotropic glutamate receptor signaling pathway [GO:0035235],
response to drug [GO:0042493],
cardiac muscle contraction [GO:0060048],
regulation of cardiac muscle cell membrane potential [GO:0086036],

Molecular Function:
beta-amyloid binding [GO:0001540],
sodium:potassium-exchanging ATPase activity [GO:0005391],
ATP binding [GO:0005524],
metal ion binding [GO:0046872],
chaperone binding [GO:0051087],
ion antiporter activity involved in regulation of presynaptic membrane potential [GO:0099520],
steroid hormone binding [GO:1990239],
nucleotide binding [GO:0000166],
potassium-transporting ATPase activity [GO:0008556],
D1 dopamine receptor binding [GO:0031748],
heparan sulfate proteoglycan binding [GO:0043395],
sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential [GO:0086037],

Cellular Component:
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
sodium:potassium-exchanging ATPase complex [GO:0005890],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
axon [GO:0030424],
neuronal cell body membrane [GO:0032809],
neuronal cell body [GO:0043025],
synapse [GO:0045202],
extracellular vesicle [GO:1903561],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
sarcolemma [GO:0042383],
myelin sheath [GO:0043209],
calyx of Held [GO:0044305],
dendritic spine neck [GO:0044326],
dendritic spine head [GO:0044327],
postsynapse [GO:0098794],
integral component of presynaptic membrane [GO:0099056],