ATP1A2

ATPase Na+/K+ transporting subunit alpha 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2, Li-Fraumeni Human YES

GO terms:

Biological Process:
neurotransmitter uptake [GO:0001504],
regulation of the force of heart contraction [GO:0002026],
regulation of respiratory gaseous exchange by neurological system process [GO:0002087],
potassium ion transport [GO:0006813],
sodium ion transport [GO:0006814],
cellular sodium ion homeostasis [GO:0006883],
regulation of smooth muscle contraction [GO:0006940],
regulation of striated muscle contraction [GO:0006942],
regulation of blood pressure [GO:0008217],
adult locomotory behavior [GO:0008344],
visual learning [GO:0008542],
establishment or maintenance of transmembrane electrochemical gradient [GO:0010248],
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881],
ATP hydrolysis coupled proton transport [GO:0015991],
regulation of vasoconstriction [GO:0019229],
cellular potassium ion homeostasis [GO:0030007],
ion transmembrane transport [GO:0034220],
response to nicotine [GO:0035094],
sodium ion export from cell [GO:0036376],
locomotion [GO:0040011],
negative regulation of heart contraction [GO:0045822],
negative regulation of striated muscle contraction [GO:0045988],
ATP metabolic process [GO:0046034],
negative regulation of cytosolic calcium ion concentration [GO:0051481],
regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051946],
regulation of synaptic transmission, glutamatergic [GO:0051966],
relaxation of cardiac muscle [GO:0055119],
cardiac muscle contraction [GO:0060048],
cellular response to mechanical stimulus [GO:0071260],
cellular response to steroid hormone stimulus [GO:0071383],
regulation of cardiac muscle cell contraction [GO:0086004],
membrane repolarization [GO:0086009],
membrane depolarization during cardiac muscle cell action potential [GO:0086012],
cell communication by electrical coupling involved in cardiac conduction [GO:0086064],
negative regulation of calcium ion transmembrane transport [GO:1903170],
negative regulation of calcium:sodium antiporter activity [GO:1903280],
response to glycoside [GO:1903416],
regulation of cardiac conduction [GO:1903779],
potassium ion import across plasma membrane [GO:1990573],
ion transport [GO:0006811],
regulation of muscle contraction [GO:0006937],

Molecular Function:
sodium:potassium-exchanging ATPase activity [GO:0005391],
protein binding [GO:0005515],
ATP binding [GO:0005524],
drug binding [GO:0008144],
ATPase activity [GO:0016887],
potassium ion binding [GO:0030955],
sodium ion binding [GO:0031402],
chaperone binding [GO:0051087],
steroid hormone binding [GO:1990239],
nucleotide binding [GO:0000166],
potassium-transporting ATPase activity [GO:0008556],
cation-transporting ATPase activity [GO:0019829],
metal ion binding [GO:0046872],

Cellular Component:
cytoplasm [GO:0005737],
endosome [GO:0005768],
plasma membrane [GO:0005886],
sodium:potassium-exchanging ATPase complex [GO:0005890],
caveola [GO:0005901],
intercalated disc [GO:0014704],
membrane [GO:0016020],
T-tubule [GO:0030315],
dendritic spine [GO:0043197],
extracellular vesicle [GO:1903561],
integral component of membrane [GO:0016021],
sarcolemma [GO:0042383],
neuron projection [GO:0043005],
myelin sheath [GO:0043209],
synapse [GO:0045202],