ATM

ATM serine/threonine kinase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
15753076 Primary hematopoietic progenitor cells Mouse NO
17136093 MRC5, BJ, IMR-90, PDVC57 Human, Mouse NO
17136094 BJ, HMEC Human NO
20639198 HUVEC Human NO
23180582 Hs294T and SK-Mel-28 cells Human NO
24934860 Primary mesenchymal stem cellsderived from endometrium Human NO
25231413 Human NO
25937285 IMR-90 Human NO
27845209 HeLa, A549, MRC-5 Human NO
28346404 HDF Heart Human NO
28724653 HUVEC Heart Mouse NO
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30657058 C4–2, LNCaP Human NO

GO terms:

Biological Process:
DNA damage checkpoint [GO:0000077],
telomere maintenance [GO:0000723],
DNA double-strand break processing [GO:0000729],
response to hypoxia [GO:0001666],
pre-B cell allelic exclusion [GO:0002331],
DNA replication [GO:0006260],
double-strand break repair via nonhomologous end joining [GO:0006303],
protein phosphorylation [GO:0006468],
cellular response to DNA damage stimulus [GO:0006974],
DNA damage induced protein phosphorylation [GO:0006975],
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977],
cell cycle arrest [GO:0007050],
mitotic spindle assembly checkpoint [GO:0007094],
reciprocal meiotic recombination [GO:0007131],
signal transduction [GO:0007165],
intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630],
response to ionizing radiation [GO:0010212],
regulation of autophagy [GO:0010506],
positive regulation of gene expression [GO:0010628],
histone phosphorylation [GO:0016572],
peptidyl-serine phosphorylation [GO:0018105],
positive regulation of cell migration [GO:0030335],
negative regulation of B cell proliferation [GO:0030889],
regulation of telomere maintenance via telomerase [GO:0032210],
positive regulation of telomere maintenance via telomerase [GO:0032212],
positive regulation of histone phosphorylation [GO:0033129],
phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092],
peptidyl-serine autophosphorylation [GO:0036289],
regulation of apoptotic process [GO:0042981],
positive regulation of apoptotic process [GO:0043065],
positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517],
positive regulation of neuron apoptotic process [GO:0043525],
positive regulation of cell adhesion [GO:0045785],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
protein autophosphorylation [GO:0046777],
regulation of telomerase activity [GO:0051972],
histone mRNA catabolic process [GO:0071044],
cellular response to retinoic acid [GO:0071300],
cellular response to gamma radiation [GO:0071480],
cellular response to X-ray [GO:0071481],
cellular response to nitrosative stress [GO:0071500],
signal transduction involved in mitotic G2 DNA damage checkpoint [GO:0072434],
replicative senescence [GO:0090399],
establishment of RNA localization to telomere [GO:0097694],
establishment of macromolecular complex localization to telomere [GO:0097695],
regulation of cellular response to heat [GO:1900034],
regulation of signal transduction by p53 class mediator [GO:1901796],
positive regulation of DNA catabolic process [GO:1903626],
regulation of microglial cell activation [GO:1903978],
negative regulation of TORC1 signaling [GO:1904262],
negative regulation of telomere capping [GO:1904354],
positive regulation of telomere maintenance via telomere lengthening [GO:1904358],
positive regulation of telomerase catalytic core complex assembly [GO:1904884],
double-strand break repair via homologous recombination [GO:0000724],
ovarian follicle development [GO:0001541],
somitogenesis [GO:0001756],
immune system process [GO:0002376],
immunoglobulin production [GO:0002377],
DNA repair [GO:0006281],
cell cycle [GO:0007049],
male meiosis [GO:0007140],
female meiotic division [GO:0007143],
female gamete generation [GO:0007292],
brain development [GO:0007420],
heart development [GO:0007507],
determination of adult lifespan [GO:0008340],
female gonad development [GO:0008585],
post-embryonic development [GO:0009791],
phosphorylation [GO:0016310],
V(D)J recombination [GO:0033151],
multicellular organism growth [GO:0035264],
lipoprotein catabolic process [GO:0042159],
meiotic telomere clustering [GO:0045141],
thymus development [GO:0048538],
oocyte development [GO:0048599],
neuron apoptotic process [GO:0051402],
regulation of cell cycle [GO:0051726],
chromosome organization involved in meiotic cell cycle [GO:0070192],
positive regulation of neuron death [GO:1901216],
positive regulation of response to DNA damage stimulus [GO:2001022],

Molecular Function:
DNA binding [GO:0003677],
protein serine/threonine kinase activity [GO:0004674],
DNA-dependent protein kinase activity [GO:0004677],
protein binding [GO:0005515],
ATP binding [GO:0005524],
1-phosphatidylinositol-3-kinase activity [GO:0016303],
macromolecular complex binding [GO:0044877],
protein dimerization activity [GO:0046983],
protein N-terminus binding [GO:0047485],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
chromosome, telomeric region [GO:0000781],
nuclear chromosome, telomeric region [GO:0000784],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
cytoplasmic vesicle [GO:0031410],
DNA repair complex [GO:1990391],
cytoplasm [GO:0005737],
spindle [GO:0005819],