ATG7

autophagy related 7

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
25144556 MRC-5, WI-38 Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
21858089 HDF Human NO
25413053 BJ Human NO
25673642 Melanoma cell lines, CNS cell lines Mouse NO

GO terms:

Biological Process:
autophagosome assembly [GO:0000045],
mitophagy [GO:0000422],
cellular protein modification process [GO:0006464],
protein lipidation [GO:0006497],
C-terminal protein lipidation [GO:0006501],
autophagy [GO:0006914],
cellular response to nitrogen starvation [GO:0006995],
aging [GO:0007568],
cellular response to starvation [GO:0009267],
response to glucose [GO:0009749],
positive regulation of autophagy [GO:0010508],
protein transport [GO:0015031],
macroautophagy [GO:0016236],
protein ubiquitination [GO:0016567],
positive regulation of protein modification process [GO:0031401],
protein modification by small protein conjugation [GO:0032446],
piecemeal microautophagy of nucleus [GO:0034727],
suppression by virus of host autophagy [GO:0039521],
regulation of circadian rhythm [GO:0042752],
positive regulation of apoptotic process [GO:0043065],
neutrophil degranulation [GO:0043312],
late nucleophagy [GO:0044805],
positive regulation of protein catabolic process [GO:0045732],
rhythmic process [GO:0048511],
defense response to virus [GO:0051607],
membrane fusion [GO:0061025],
chaperone-mediated autophagy [GO:0061684],
cellular response to morphine [GO:0071315],
cellular response to hyperoxia [GO:0071455],
autophagy of host cells involved in interaction with symbiont [GO:0075044],
negative regulation of mitochondrial DNA replication [GO:0090298],
response to fluoride [GO:1902617],
negative regulation of oxidative stress-induced neuron death [GO:1903204],
liver development [GO:0001889],
organelle organization [GO:0006996],
mitochondrion organization [GO:0007005],
adult walking behavior [GO:0007628],
post-embryonic development [GO:0009791],
cellular homeostasis [GO:0019725],
cerebellar Purkinje cell layer development [GO:0021680],
pyramidal neuron development [GO:0021860],
central nervous system neuron axonogenesis [GO:0021955],
cerebral cortex development [GO:0021987],
protein catabolic process [GO:0030163],
neuron projection development [GO:0031175],
regulation of protein ubiquitination [GO:0031396],
positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436],
cellular response to reactive oxygen species [GO:0034614],
positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774],
negative stranded viral RNA replication [GO:0039689],
response to starvation [GO:0042594],
negative regulation of apoptotic process [GO:0043066],
negative regulation of phagocytosis [GO:0050765],
neurological system process [GO:0050877],
cardiac muscle cell development [GO:0055013],
regulation of cell development [GO:0060284],
negative regulation of cell death [GO:0060548],
membrane organization [GO:0061024],
positive regulation of mucus secretion [GO:0070257],
amino acid homeostasis [GO:0080144],
negative regulation of sphingolipid biosynthetic process [GO:0090155],
cellular sphingolipid homeostasis [GO:0090156],
regulation of neuron death [GO:1901214],
regulation of hemopoiesis [GO:1903706],
negative regulation of histone H4-K16 acetylation [GO:2000619],

Molecular Function:
ubiquitin activating enzyme activity [GO:0004839],
protein binding [GO:0005515],
transcription factor binding [GO:0008134],
Atg12 activating enzyme activity [GO:0019778],
Atg8 activating enzyme activity [GO:0019779],
protein homodimerization activity [GO:0042803],
small protein activating enzyme activity [GO:0008641],

Cellular Component:
pre-autophagosomal structure [GO:0000407],
extracellular region [GO:0005576],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
axoneme [GO:0005930],
axon [GO:0030424],
secretory granule lumen [GO:0034774],
ficolin-1-rich granule lumen [GO:1904813],
perinuclear region of cytoplasm [GO:0048471],