ATF6

activating transcription factor 6

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27563820 NHDF Human NO
28803844 NHDF Human NO
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA71 Skin, Lung Human YES
30213560 NHEK Human NO

GO terms:

Biological Process:
eye development [GO:0001654],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
protein folding [GO:0006457],
signal transduction [GO:0007165],
visual perception [GO:0007601],
endoplasmic reticulum unfolded protein response [GO:0030968],
ATF6-mediated unfolded protein response [GO:0036500],
positive regulation of apoptotic process [GO:0043065],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of ATF6-mediated unfolded protein response [GO:1903893],
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440],
regulation of transcription, DNA-templated [GO:0006355],
response to unfolded protein [GO:0006986],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
transcription coactivator activity [GO:0003713],
protein binding [GO:0005515],
ubiquitin protein ligase binding [GO:0031625],
cAMP response element binding [GO:0035497],
identical protein binding [GO:0042802],
sequence-specific DNA binding [GO:0043565],
protein heterodimerization activity [GO:0046982],
DNA binding [GO:0003677],

Cellular Component:
Golgi membrane [GO:0000139],
nucleus [GO:0005634],
nuclear envelope [GO:0005635],
nucleoplasm [GO:0005654],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
membrane [GO:0016020],
integral component of endoplasmic reticulum membrane [GO:0030176],
integral component of membrane [GO:0016021],