ATF2

activating transcription factor 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
19082758 IMR-90 Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
outflow tract morphogenesis [GO:0003151],
regulation of transcription, DNA-templated [GO:0006355],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
response to osmotic stress [GO:0006970],
cellular response to DNA damage stimulus [GO:0006974],
response to water deprivation [GO:0009414],
positive regulation of gene expression [GO:0010628],
negative regulation of angiogenesis [GO:0016525],
histone acetylation [GO:0016573],
intra-S DNA damage checkpoint [GO:0031573],
positive regulation of transforming growth factor beta2 production [GO:0032915],
positive regulation of neuron apoptotic process [GO:0043525],
fat cell differentiation [GO:0045444],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
negative regulation of epithelial cell proliferation [GO:0050680],
regulation of sequence-specific DNA binding transcription factor activity [GO:0051090],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
adipose tissue development [GO:0060612],
amelogenesis [GO:0097186],
positive regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902110],

Molecular Function:
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II distal enhancer sequence-specific DNA binding [GO:0000980],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
RNA polymerase II activating transcription factor binding [GO:0001102],
enhancer sequence-specific DNA binding [GO:0001158],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
chromatin binding [GO:0003682],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
histone acetyltransferase activity [GO:0004402],
protein binding [GO:0005515],
cAMP response element binding protein binding [GO:0008140],
protein kinase binding [GO:0019901],
cAMP response element binding [GO:0035497],
metal ion binding [GO:0046872],
protein heterodimerization activity [GO:0046982],
nucleic acid binding [GO:0003676],
DNA binding [GO:0003677],
transcription factor binding [GO:0008134],
transferase activity [GO:0016740],
sequence-specific DNA binding [GO:0043565],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrial outer membrane [GO:0005741],
site of double-strand break [GO:0035861],
mitochondrion [GO:0005739],
membrane [GO:0016020],