ASPM

abnormal spindle microtubule assembly

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2 Human YES

GO terms:

Biological Process:
neuron migration [GO:0001764],
positive regulation of neuroblast proliferation [GO:0002052],
cell cycle [GO:0007049],
spindle organization [GO:0007051],
spermatogenesis [GO:0007283],
brain development [GO:0007420],
male gonad development [GO:0008584],
forebrain neuroblast division [GO:0021873],
cerebral cortex development [GO:0021987],
negative regulation of neuron differentiation [GO:0045665],
negative regulation of asymmetric cell division [GO:0045769],
oogenesis [GO:0048477],
developmental growth [GO:0048589],
cell division [GO:0051301],
regulation of meiotic cell cycle [GO:0051445],
spindle localization [GO:0051653],
maintenance of centrosome location [GO:0051661],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
spindle assembly involved in meiosis [GO:0090306],
neuronal stem cell population maintenance [GO:0097150],

Molecular Function:
calmodulin binding [GO:0005516],

Cellular Component:
spindle pole [GO:0000922],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
centrosome [GO:0005813],
cytoskeleton [GO:0005856],
microtubule [GO:0005874],
apical plasma membrane [GO:0016324],
midbody [GO:0030496],
microtubule minus-end [GO:0036449],
meiotic spindle [GO:0072687],
mitotic spindle pole [GO:0097431],