ASPH

aspartate beta-hydroxylase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2, Li-Fraumeni Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
26683595 CVCL_7955, HepG2, Huh7 Liver Human NO

GO terms:

Biological Process:
muscle contraction [GO:0006936],
pattern specification process [GO:0007389],
negative regulation of cell proliferation [GO:0008285],
electron transport chain [GO:0022900],
regulation of protein stability [GO:0031647],
ion transmembrane transport [GO:0034220],
limb morphogenesis [GO:0035108],
peptidyl-aspartic acid hydroxylation [GO:0042264],
positive regulation of proteolysis [GO:0045862],
palate development [GO:0060021],
face morphogenesis [GO:0060325],
activation of cysteine-type endopeptidase activity [GO:0097202],
regulation of protein depolymerization [GO:1901879],
regulation of cardiac conduction [GO:1903779],
positive regulation of calcium ion transport into cytosol [GO:0010524],
peptidyl-amino acid modification [GO:0018193],
regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [GO:0031585],
activation of store-operated calcium channel activity [GO:0032237],
response to ATP [GO:0033198],
positive regulation of transcription, DNA-templated [GO:0045893],
regulation of cytosolic calcium ion concentration [GO:0051480],
oxidation-reduction process [GO:0055114],
calcium ion transmembrane transport [GO:0070588],
cellular response to calcium ion [GO:0071277],
positive regulation of intracellular protein transport [GO:0090316],

Molecular Function:
peptide-aspartate beta-dioxygenase activity [GO:0004597],
structural molecule activity [GO:0005198],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
structural constituent of muscle [GO:0008307],
electron carrier activity [GO:0009055],
oxidoreductase activity [GO:0016491],
metal ion binding [GO:0046872],
dioxygenase activity [GO:0051213],

Cellular Component:
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
plasma membrane [GO:0005886],
integral component of membrane [GO:0016021],
cortical endoplasmic reticulum [GO:0032541],
sarcoplasmic reticulum membrane [GO:0033017],
cytoplasm [GO:0005737],
membrane [GO:0016020],
sarcoplasmic reticulum [GO:0016529],
integral component of endoplasmic reticulum membrane [GO:0030176],