MFN2

mitofusin 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA811 Skin, Lung Human YES

GO terms:

Biological Process:
blastocyst formation [GO:0001825],
protein targeting to mitochondrion [GO:0006626],
apoptotic process [GO:0006915],
response to unfolded protein [GO:0006986],
mitochondrial membrane organization [GO:0007006],
cell cycle arrest [GO:0007050],
blood coagulation [GO:0007596],
mitochondrial fusion [GO:0008053],
macroautophagy [GO:0016236],
protein localization to pre-autophagosomal structure [GO:0034497],
negative regulation of Ras protein signal transduction [GO:0046580],
camera-type eye morphogenesis [GO:0048593],
negative regulation of smooth muscle cell proliferation [GO:0048662],
mitochondrion localization [GO:0051646],
parkin-mediated mitophagy in response to mitochondrial depolarization [GO:0061734],
positive regulation of vascular smooth muscle cell proliferation [GO:1904707],
positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461],
autophagy [GO:0006914],
multicellular organism development [GO:0007275],

Molecular Function:
GTPase activity [GO:0003924],
protein binding [GO:0005515],
GTP binding [GO:0005525],
ubiquitin protein ligase binding [GO:0031625],
nucleotide binding [GO:0000166],
hydrolase activity [GO:0016787],
Ras GTPase binding [GO:0017016],
protein homodimerization activity [GO:0042803],
proteoglycan binding [GO:0043394],
GTPase binding [GO:0051020],

Cellular Component:
mitochondrion [GO:0005739],
mitochondrial outer membrane [GO:0005741],
cytosol [GO:0005829],
microtubule cytoskeleton [GO:0015630],
integral component of membrane [GO:0016021],
intrinsic component of mitochondrial outer membrane [GO:0031306],
cytoplasm [GO:0005737],
membrane [GO:0016020],