AT-rich interaction domain 5B

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA28 Skin, Lung Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
kidney development [GO:0001822],
regulation of transcription, DNA-templated [GO:0006355],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
nitrogen compound metabolic process [GO:0006807],
male gonad development [GO:0008584],
female gonad development [GO:0008585],
post-embryonic development [GO:0009791],
fibroblast migration [GO:0010761],
adrenal gland development [GO:0030325],
multicellular organism growth [GO:0035264],
fat cell differentiation [GO:0045444],
platelet-derived growth factor receptor signaling pathway [GO:0048008],
cell development [GO:0048468],
muscle organ morphogenesis [GO:0048644],
skeletal system morphogenesis [GO:0048705],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
palate development [GO:0060021],
face morphogenesis [GO:0060325],
adipose tissue development [GO:0060612],
fat pad development [GO:0060613],
cellular response to leukemia inhibitory factor [GO:1990830],
liver development [GO:0001889],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of nucleic acid-templated transcription [GO:1903508],

Molecular Function:
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
DNA binding [GO:0003677],
transcription coactivator activity [GO:0003713],
transcription regulatory region DNA binding [GO:0044212],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
protein binding [GO:0005515],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],