ARHGDIG

Rho GDP dissociation inhibitor gamma

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

GO terms:

Biological Process:
blastocyst hatching [GO:0001835],
negative regulation of cell adhesion [GO:0007162],
Rho protein signal transduction [GO:0007266],
regulation of protein localization [GO:0032880],
positive regulation of GTPase activity [GO:0043547],
regulation of small GTPase mediated signal transduction [GO:0051056],

Molecular Function:
Rho GDP-dissociation inhibitor activity [GO:0005094],
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
Rac GTPase binding [GO:0048365],
GDP-dissociation inhibitor activity [GO:0005092],
GTPase regulator activity [GO:0030695],

Cellular Component:
cytosol [GO:0005829],
plasma membrane [GO:0005886],
membrane [GO:0016020],
cytoplasmic vesicle [GO:0031410],
cytoplasm [GO:0005737],