ARHGAP35

Rho GTPase activating protein 35

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
neural tube closure [GO:0001843],
transcription, DNA-templated [GO:0006351],
signal transduction [GO:0007165],
axon guidance [GO:0007411],
axonal fasciculation [GO:0007413],
regulation of actin polymerization or depolymerization [GO:0008064],
regulation of cell shape [GO:0008360],
positive regulation of neuron projection development [GO:0010976],
cell migration [GO:0016477],
central nervous system neuron axonogenesis [GO:0021955],
mammary gland development [GO:0030879],
forebrain development [GO:0030900],
establishment or maintenance of actin cytoskeleton polarity [GO:0030950],
cellular response to extracellular stimulus [GO:0031668],
regulation of actin cytoskeleton organization [GO:0032956],
negative regulation of Rho protein signal transduction [GO:0035024],
camera-type eye development [GO:0043010],
negative regulation of vascular permeability [GO:0043116],
positive regulation of GTPase activity [GO:0043547],
wound healing, spreading of cells [GO:0044319],
positive regulation of cilium assembly [GO:0045724],
negative regulation of transcription, DNA-templated [GO:0045892],
regulation of axonogenesis [GO:0050770],
regulation of small GTPase mediated signal transduction [GO:0051056],
neuron projection guidance [GO:0097485],
integrin-mediated signaling pathway [GO:0007229],

Molecular Function:
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
DNA binding [GO:0003677],
transcription corepressor activity [GO:0003714],
GTPase activity [GO:0003924],
GTPase activator activity [GO:0005096],
GTP binding [GO:0005525],
phospholipid binding [GO:0005543],
nucleotide binding [GO:0000166],
lipid binding [GO:0008289],
GTPase activating protein binding [GO:0032794],
macromolecular complex binding [GO:0044877],

Cellular Component:
nucleus [GO:0005634],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
actin cytoskeleton [GO:0015629],
ciliary basal body [GO:0036064],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],
membrane [GO:0016020],
cell projection [GO:0042995],