ARG2

arginase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
23832324 HUVEC Aorta Human NO
25635535 HUVEC Heart and thoracic aortas Human, mouse NO
28627081 Skin Human NO
28943853 Mouse NO
29472548 HUVSMC Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
urea cycle [GO:0000050],
ureteric bud development [GO:0001657],
adaptive immune response [GO:0002250],
negative regulation of type 2 immune response [GO:0002829],
nitric oxide biosynthetic process [GO:0006809],
striated muscle contraction [GO:0006941],
arginine catabolic process to ornithine [GO:0019547],
negative regulation of tumor necrosis factor production [GO:0032720],
innate immune response [GO:0045087],
regulation of interleukin-1 beta secretion [GO:0050706],
negative regulation of macrophage inflammatory protein 1 alpha production [GO:0071641],
negative regulation of chemokine (C-C motif) ligand 4 production [GO:0071644],
negative regulation of chemokine (C-C motif) ligand 5 production [GO:0071650],
negative regulation of defense response to bacterium [GO:1900425],
regulation of reactive oxygen species biosynthetic process [GO:1903426],
negative regulation of tumor necrosis factor secretion [GO:1904468],
negative regulation of interleukin-17 secretion [GO:1905077],
negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process [GO:1905403],
negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562],
negative regulation of interleukin-13 secretion [GO:2000666],
positive regulation of cellular senescence [GO:2000774],
immune system process [GO:0002376],
arginine metabolic process [GO:0006525],
regulation of L-arginine import [GO:0010963],
negative regulation of striated muscle contraction [GO:0045988],
negative regulation of nitric-oxide synthase activity [GO:0051001],

Molecular Function:
arginase activity [GO:0004053],
manganese ion binding [GO:0030145],
hydrolase activity [GO:0016787],
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [GO:0016813],
metal ion binding [GO:0046872],
nitric-oxide synthase binding [GO:0050998],

Cellular Component:
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
mitochondrial matrix [GO:0005759],