ARG1

arginase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28153047 HUVEC Human NO

GO terms:

Biological Process:
urea cycle [GO:0000050],
liver development [GO:0001889],
positive regulation of endothelial cell proliferation [GO:0001938],
adaptive immune response [GO:0002250],
arginine catabolic process [GO:0006527],
aging [GO:0007568],
response to herbicide [GO:0009635],
response to manganese ion [GO:0010042],
response to zinc ion [GO:0010043],
response to selenium ion [GO:0010269],
regulation of L-arginine import [GO:0010963],
response to amine [GO:0014075],
arginine catabolic process to ornithine [GO:0019547],
lung development [GO:0030324],
collagen biosynthetic process [GO:0032964],
response to vitamin A [GO:0033189],
response to vitamin E [GO:0033197],
negative regulation of T cell proliferation [GO:0042130],
defense response to protozoan [GO:0042832],
response to amino acid [GO:0043200],
neutrophil degranulation [GO:0043312],
innate immune response [GO:0045087],
negative regulation of activated T cell proliferation [GO:0046007],
response to cadmium ion [GO:0046686],
response to axon injury [GO:0048678],
response to methylmercury [GO:0051597],
mammary gland involution [GO:0060056],
maternal process involved in female pregnancy [GO:0060135],
negative regulation of interferon-gamma-mediated signaling pathway [GO:0060336],
protein homotrimerization [GO:0070207],
cellular response to hydrogen peroxide [GO:0070301],
positive regulation of neutrophil mediated killing of fungus [GO:0070965],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to interleukin-4 [GO:0071353],
cellular response to glucagon stimulus [GO:0071377],
cellular response to dexamethasone stimulus [GO:0071549],
cellular response to transforming growth factor beta stimulus [GO:0071560],
negative regulation of T-helper 2 cell cytokine production [GO:2000552],
immune system process [GO:0002376],
arginine metabolic process [GO:0006525],

Molecular Function:
arginase activity [GO:0004053],
protein binding [GO:0005515],
manganese ion binding [GO:0030145],
hydrolase activity [GO:0016787],
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [GO:0016813],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
mitochondrial outer membrane [GO:0005741],
cytosol [GO:0005829],
azurophil granule lumen [GO:0035578],
specific granule lumen [GO:0035580],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],