AREG

amphiregulin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
ER to Golgi vesicle-mediated transport [GO:0006888],
signal transduction [GO:0007165],
epidermal growth factor receptor signaling pathway [GO:0007173],
G-protein coupled receptor signaling pathway [GO:0007186],
cell-cell signaling [GO:0007267],
cell proliferation [GO:0008283],
positive regulation of cell proliferation [GO:0008284],
regulation of receptor activity [GO:0010469],
glial cell proliferation [GO:0014009],
neuron projection development [GO:0031175],
response to estradiol [GO:0032355],
negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059],
response to hydrogen peroxide [GO:0042542],
response to peptide hormone [GO:0043434],
negative regulation of osteoblast differentiation [GO:0045668],
COPII vesicle coating [GO:0048208],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
response to glucocorticoid [GO:0051384],
response to cAMP [GO:0051591],
positive regulation of protein kinase B signaling [GO:0051897],
dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis [GO:0060598],
mammary gland branching involved in thelarche [GO:0060744],
mammary gland alveolus development [GO:0060749],
epithelial cell proliferation involved in mammary gland duct elongation [GO:0060750],
membrane organization [GO:0061024],
positive regulation of phosphorylation [GO:0042327],

Molecular Function:
cytokine activity [GO:0005125],
epidermal growth factor receptor binding [GO:0005154],
protein binding [GO:0005515],
growth factor activity [GO:0008083],

Cellular Component:
Golgi membrane [GO:0000139],
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
endoplasmic reticulum membrane [GO:0005789],
cell surface [GO:0009986],
ER to Golgi transport vesicle membrane [GO:0012507],
integral component of membrane [GO:0016021],
clathrin-coated vesicle membrane [GO:0030665],
endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116],
cytoplasm [GO:0005737],
membrane [GO:0016020],