AQP1

aquaporin 1 (Colton blood group)

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2, Li-Fraumeni Human YES

GO terms:

Biological Process:
renal water homeostasis [GO:0003091],
renal water transport [GO:0003097],
potassium ion transport [GO:0006813],
water transport [GO:0006833],
cell volume homeostasis [GO:0006884],
hyperosmotic response [GO:0006972],
carbon dioxide transport [GO:0015670],
ammonium transport [GO:0015696],
bicarbonate transport [GO:0015701],
glycerol transport [GO:0015793],
cellular homeostasis [GO:0019725],
cGMP-mediated signaling [GO:0019934],
lateral ventricle development [GO:0021670],
pancreatic juice secretion [GO:0030157],
nitric oxide transport [GO:0030185],
establishment or maintenance of actin cytoskeleton polarity [GO:0030950],
cerebrospinal fluid secretion [GO:0033326],
cellular response to UV [GO:0034644],
transepithelial water transport [GO:0035377],
carbon dioxide transmembrane transport [GO:0035378],
odontogenesis [GO:0042476],
response to drug [GO:0042493],
negative regulation of apoptotic process [GO:0043066],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
positive regulation of angiogenesis [GO:0045766],
positive regulation of saliva secretion [GO:0046878],
positive regulation of fibroblast proliferation [GO:0048146],
multicellular organismal water homeostasis [GO:0050891],
cellular response to hydrogen peroxide [GO:0070301],
cellular response to inorganic substance [GO:0071241],
cellular response to mechanical stimulus [GO:0071260],
cellular response to copper ion [GO:0071280],
cellular response to mercury ion [GO:0071288],
cellular response to retinoic acid [GO:0071300],
cellular response to cAMP [GO:0071320],
cellular response to hypoxia [GO:0071456],
cellular response to salt stress [GO:0071472],
cellular hyperosmotic response [GO:0071474],
cellular response to dexamethasone stimulus [GO:0071549],
cellular response to nitric oxide [GO:0071732],
potassium ion transmembrane transport [GO:0071805],
ammonium transmembrane transport [GO:0072488],
maintenance of symbiont-containing vacuole by host [GO:0085018],
glomerular filtration [GO:0003094],
positive regulation of lamellipodium assembly [GO:0010592],
positive regulation of epithelial cell migration [GO:0010634],
sensory perception of pain [GO:0019233],
water homeostasis [GO:0030104],
positive regulation of cell migration [GO:0030335],
secretion by cell [GO:0032940],
secretory granule organization [GO:0033363],
wound healing [GO:0042060],
lipid digestion [GO:0044241],
camera-type eye morphogenesis [GO:0048593],
corticotropin secretion [GO:0051458],
transmembrane transport [GO:0055085],
renal water absorption [GO:0070295],
metanephric descending thin limb development [GO:0072220],
metanephric proximal straight tubule development [GO:0072230],
metanephric proximal convoluted tubule segment 2 development [GO:0072232],
metanephric glomerulus vasculature development [GO:0072239],

Molecular Function:
intracellular cGMP activated cation channel activity [GO:0005223],
potassium channel activity [GO:0005267],
water transmembrane transporter activity [GO:0005372],
protein binding [GO:0005515],
ammonium transmembrane transporter activity [GO:0008519],
potassium ion transmembrane transporter activity [GO:0015079],
glycerol transmembrane transporter activity [GO:0015168],
water channel activity [GO:0015250],
transmembrane transporter activity [GO:0022857],
nitric oxide transmembrane transporter activity [GO:0030184],
carbon dioxide transmembrane transporter activity [GO:0035379],
identical protein binding [GO:0042802],
channel activity [GO:0015267],
ephrin receptor binding [GO:0046875],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
brush border [GO:0005903],
basal plasma membrane [GO:0009925],
integral component of membrane [GO:0016021],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],
symbiont-containing vacuole [GO:0020003],
symbiont-containing vacuole membrane [GO:0020005],
brush border membrane [GO:0031526],
nuclear membrane [GO:0031965],
sarcolemma [GO:0042383],
apical part of cell [GO:0045177],
extracellular exosome [GO:0070062],
caveola [GO:0005901],
membrane [GO:0016020],
axon [GO:0030424],
dense core granule membrane [GO:0032127],
neuronal cell body membrane [GO:0032809],
neuron projection [GO:0043005],
axon terminus [GO:0043679],