KLF4

Kruppel like factor 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27531889 T-REx-293 KLF4, T-REx-293 PC4, T-REx-HeLa KLF4 Esophagus Human NO
29548335 Saos-2 Human YES
30987592 MCF7 Breast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27696667 HASMS Human NO
28410532 Dental pulp stem cells Human NO
29580988 HEK Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
transcription from RNA polymerase II promoter [GO:0006366],
mesodermal cell fate determination [GO:0007500],
negative regulation of cell proliferation [GO:0008285],
epidermal cell differentiation [GO:0009913],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067],
negative regulation of muscle hyperplasia [GO:0014740],
negative regulation of angiogenesis [GO:0016525],
stem cell population maintenance [GO:0019827],
post-embryonic camera-type eye development [GO:0031077],
negative regulation of NF-kappaB transcription factor activity [GO:0032088],
positive regulation of cellular protein metabolic process [GO:0032270],
negative regulation of heterotypic cell-cell adhesion [GO:0034115],
somatic stem cell population maintenance [GO:0035019],
post-embryonic hemopoiesis [GO:0035166],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
regulation of phosphatidylinositol 3-kinase activity [GO:0043551],
negative regulation of interleukin-8 biosynthetic process [GO:0045415],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
fat cell differentiation [GO:0045444],
regulation of cell differentiation [GO:0045595],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of hemoglobin biosynthetic process [GO:0046985],
negative regulation of smooth muscle cell proliferation [GO:0048662],
regulation of axon regeneration [GO:0048679],
epidermis morphogenesis [GO:0048730],
negative regulation of inflammatory response [GO:0050728],
positive regulation of protein metabolic process [GO:0051247],
negative regulation of protein kinase B signaling [GO:0051898],
positive regulation of telomerase activity [GO:0051973],
canonical Wnt signaling pathway [GO:0060070],
negative regulation of response to cytokine stimulus [GO:0060761],
pri-miRNA transcription from RNA polymerase II promoter [GO:0061614],
cellular response to hydrogen peroxide [GO:0070301],
negative regulation of ERK1 and ERK2 cascade [GO:0070373],
cellular response to retinoic acid [GO:0071300],
cellular response to growth factor stimulus [GO:0071363],
cellular response to cycloheximide [GO:0071409],
cellular response to laminar fluid shear stress [GO:0071499],
negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051],
cellular response to peptide [GO:1901653],
positive regulation of sprouting angiogenesis [GO:1903672],
positive regulation of core promoter binding [GO:1904798],
negative regulation of leukocyte adhesion to arterial endothelial cell [GO:1904998],
cellular response to leukemia inhibitory factor [GO:1990830],
negative regulation of G1/S transition of mitotic cell cycle [GO:2000134],
negative regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000342],
transcription, DNA-templated [GO:0006351],
response to organic substance [GO:0010033],
cell differentiation [GO:0030154],
negative regulation of cell migration [GO:0030336],
response to retinoic acid [GO:0032526],
regulation of cell proliferation [GO:0042127],
negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433],

Molecular Function:
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
core promoter proximal region sequence-specific DNA binding [GO:0000987],
transcription factor activity, sequence-specific DNA binding transcription factor recruiting [GO:0001010],
RNA polymerase II transcription factor binding [GO:0001085],
transcription cofactor binding [GO:0001221],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
zinc ion binding [GO:0008270],
phosphatidylinositol 3-kinase regulator activity [GO:0035014],
histone deacetylase binding [GO:0042826],
transcription regulatory region DNA binding [GO:0044212],
promoter-specific chromatin binding [GO:1990841],
nucleic acid binding [GO:0003676],
DNA binding [GO:0003677],
double-stranded DNA binding [GO:0003690],
transcription factor binding [GO:0008134],
sequence-specific DNA binding [GO:0043565],
metal ion binding [GO:0046872],

Cellular Component:
nuclear chromatin [GO:0000790],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nuclear euchromatin [GO:0005719],
cytoplasm [GO:0005737],
nuclear transcription factor complex [GO:0044798],
chromatin [GO:0000785],
transcription factor complex [GO:0005667],