APP

amyloid beta precursor protein

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21678067 C-85 Human NO
27453234 Primary neurons derived from brain Brain Mouse NO
30936558 Primary oligodendrocyte progenitor cells Brain Human, mouse NO

GO terms:

Biological Process:
positive regulation of protein phosphorylation [GO:0001934],
suckling behavior [GO:0001967],
astrocyte activation involved in immune response [GO:0002265],
platelet degranulation [GO:0002576],
mRNA polyadenylation [GO:0006378],
regulation of translation [GO:0006417],
protein phosphorylation [GO:0006468],
cellular copper ion homeostasis [GO:0006878],
endocytosis [GO:0006897],
response to oxidative stress [GO:0006979],
cell adhesion [GO:0007155],
regulation of epidermal growth factor-activated receptor activity [GO:0007176],
G-protein coupled receptor signaling pathway [GO:0007186],
Notch signaling pathway [GO:0007219],
axonogenesis [GO:0007409],
learning or memory [GO:0007611],
learning [GO:0007612],
mating behavior [GO:0007617],
locomotory behavior [GO:0007626],
axo-dendritic transport [GO:0008088],
cholesterol metabolic process [GO:0008203],
negative regulation of cell proliferation [GO:0008285],
adult locomotory behavior [GO:0008344],
visual learning [GO:0008542],
cellular process [GO:0009987],
response to lead ion [GO:0010288],
regulation of gene expression [GO:0010468],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
positive regulation of peptidyl-threonine phosphorylation [GO:0010800],
negative regulation of endopeptidase activity [GO:0010951],
positive regulation of peptidase activity [GO:0010952],
positive regulation of G2/M transition of mitotic cell cycle [GO:0010971],
microglia development [GO:0014005],
axon midline choice point recognition [GO:0016199],
neuron remodeling [GO:0016322],
dendrite development [GO:0016358],
regulation of Wnt signaling pathway [GO:0030111],
extracellular matrix organization [GO:0030198],
forebrain development [GO:0030900],
neuron projection development [GO:0031175],
positive regulation of protein binding [GO:0032092],
tumor necrosis factor production [GO:0032640],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
ionotropic glutamate receptor signaling pathway [GO:0035235],
regulation of multicellular organism growth [GO:0040014],
positive regulation of phosphorylation [GO:0042327],
positive regulation of tumor necrosis factor biosynthetic process [GO:0042535],
post-translational protein modification [GO:0043687],
cellular protein metabolic process [GO:0044267],
positive regulation of chemokine biosynthetic process [GO:0045080],
innate immune response [GO:0045087],
positive regulation of interleukin-6 biosynthetic process [GO:0045410],
negative regulation of neuron differentiation [GO:0045665],
positive regulation of mitotic cell cycle [GO:0045931],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of JNK cascade [GO:0046330],
astrocyte activation [GO:0048143],
regulation of long-term neuronal synaptic plasticity [GO:0048169],
collateral sprouting in absence of injury [GO:0048669],
positive regulation of interleukin-1 beta biosynthetic process [GO:0050725],
regulation of peptidyl-tyrosine phosphorylation [GO:0050730],
regulation of synapse structure or activity [GO:0050803],
synapse organization [GO:0050808],
neuromuscular process controlling balance [GO:0050885],
cognition [GO:0050890],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
synaptic growth at neuromuscular junction [GO:0051124],
positive regulation of protein metabolic process [GO:0051247],
neuron apoptotic process [GO:0051402],
smooth endoplasmic reticulum calcium ion homeostasis [GO:0051563],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
response to interleukin-1 [GO:0070555],
cellular response to copper ion [GO:0071280],
cellular response to manganese ion [GO:0071287],
cellular response to cAMP [GO:0071320],
cellular response to norepinephrine stimulus [GO:0071874],
modulation of age-related behavioral decline [GO:0090647],
modulation of excitatory postsynaptic potential [GO:0098815],
negative regulation of long-term synaptic potentiation [GO:1900272],
positive regulation of long-term synaptic potentiation [GO:1900273],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
positive regulation of beta-amyloid formation [GO:1902004],
positive regulation of microglial cell activation [GO:1903980],
cellular response to beta-amyloid [GO:1904646],
amyloid fibril formation [GO:1990000],
cellular response to nerve growth factor stimulus [GO:1990090],
neuron projection maintenance [GO:1990535],
positive regulation of receptor activity [GO:2000273],
regulation of N-methyl-D-aspartate selective glutamate receptor activity [GO:2000310],
positive regulation of T cell migration [GO:2000406],
apoptotic process [GO:0006915],
nervous system development [GO:0007399],
memory [GO:0007613],
negative regulation of peptidase activity [GO:0010466],
regulation of protein binding [GO:0043393],
protein homooligomerization [GO:0051260],
long-term synaptic potentiation [GO:0060291],

Molecular Function:
DNA binding [GO:0003677],
serine-type endopeptidase inhibitor activity [GO:0004867],
receptor binding [GO:0005102],
protein binding [GO:0005515],
heparin binding [GO:0008201],
peptidase activator activity [GO:0016504],
enzyme binding [GO:0019899],
receptor activator activity [GO:0030546],
identical protein binding [GO:0042802],
transition metal ion binding [GO:0046914],
PTB domain binding [GO:0051425],
growth factor receptor binding [GO:0070851],
peptidase inhibitor activity [GO:0030414],
metal ion binding [GO:0046872],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nuclear envelope lumen [GO:0005641],
cytoplasm [GO:0005737],
endosome [GO:0005768],
early endosome [GO:0005769],
endoplasmic reticulum lumen [GO:0005788],
smooth endoplasmic reticulum [GO:0005790],
rough endoplasmic reticulum [GO:0005791],
Golgi apparatus [GO:0005794],
Golgi lumen [GO:0005796],
Golgi-associated vesicle [GO:0005798],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
clathrin-coated pit [GO:0005905],
cell-cell junction [GO:0005911],
synaptic vesicle [GO:0008021],
cell surface [GO:0009986],
integral component of membrane [GO:0016021],
ER to Golgi transport vesicle [GO:0030134],
axon [GO:0030424],
platelet alpha granule lumen [GO:0031093],
neuromuscular junction [GO:0031594],
endosome lumen [GO:0031904],
trans-Golgi network membrane [GO:0032588],
ciliary rootlet [GO:0035253],
dendritic spine [GO:0043197],
dendritic shaft [GO:0043198],
perikaryon [GO:0043204],
receptor complex [GO:0043235],
main axon [GO:0044304],
membrane raft [GO:0045121],
apical part of cell [GO:0045177],
synapse [GO:0045202],
perinuclear region of cytoplasm [GO:0048471],
presynaptic active zone [GO:0048786],
spindle midzone [GO:0051233],
recycling endosome [GO:0055037],
extracellular exosome [GO:0070062],
astrocyte projection [GO:0097449],
growth cone lamellipodium [GO:1990761],
growth cone filopodium [GO:1990812],
nucleus [GO:0005634],
membrane [GO:0016020],
growth cone [GO:0030426],
cytoplasmic vesicle [GO:0031410],
cell projection [GO:0042995],
neuron projection [GO:0043005],