APOE

apolipoprotein E

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES
30987592 MCF7 Breast Human YES

GO terms:

Biological Process:
response to reactive oxygen species [GO:0000302],
retinoid metabolic process [GO:0001523],
negative regulation of endothelial cell proliferation [GO:0001937],
response to dietary excess [GO:0002021],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
triglyceride metabolic process [GO:0006641],
cholesterol biosynthetic process [GO:0006695],
cholesterol catabolic process [GO:0006707],
cellular calcium ion homeostasis [GO:0006874],
receptor-mediated endocytosis [GO:0006898],
cytoskeleton organization [GO:0007010],
G-protein coupled receptor signaling pathway [GO:0007186],
nitric oxide mediated signal transduction [GO:0007263],
synaptic transmission, cholinergic [GO:0007271],
long-term memory [GO:0007616],
cholesterol metabolic process [GO:0008203],
negative regulation of platelet activation [GO:0010544],
negative regulation of gene expression [GO:0010629],
positive regulation of cholesterol esterification [GO:0010873],
positive regulation of cholesterol efflux [GO:0010875],
lipid transport involved in lipid storage [GO:0010877],
positive regulation of neuron projection development [GO:0010976],
negative regulation of neuron projection development [GO:0010977],
long-chain fatty acid transport [GO:0015909],
protein import [GO:0017038],
virion assembly [GO:0019068],
triglyceride catabolic process [GO:0019433],
cGMP-mediated signaling [GO:0019934],
negative regulation of blood coagulation [GO:0030195],
regulation of axon extension [GO:0030516],
neuron projection development [GO:0031175],
negative regulation of cellular protein metabolic process [GO:0032269],
regulation of cholesterol transport [GO:0032374],
regulation of protein homooligomerization [GO:0032462],
regulation of Cdc42 protein signal transduction [GO:0032489],
positive regulation of low-density lipoprotein particle receptor catabolic process [GO:0032805],
cholesterol efflux [GO:0033344],
phospholipid efflux [GO:0033700],
chylomicron remodeling [GO:0034371],
very-low-density lipoprotein particle remodeling [GO:0034372],
low-density lipoprotein particle remodeling [GO:0034374],
high-density lipoprotein particle remodeling [GO:0034375],
chylomicron assembly [GO:0034378],
high-density lipoprotein particle assembly [GO:0034380],
chylomicron remnant clearance [GO:0034382],
high-density lipoprotein particle clearance [GO:0034384],
very-low-density lipoprotein particle clearance [GO:0034447],
locomotory exploration behavior [GO:0035641],
lipoprotein metabolic process [GO:0042157],
lipoprotein biosynthetic process [GO:0042158],
lipoprotein catabolic process [GO:0042159],
vasodilation [GO:0042311],
cholesterol homeostasis [GO:0042632],
amyloid precursor protein metabolic process [GO:0042982],
negative regulation of MAP kinase activity [GO:0043407],
negative regulation of neuron apoptotic process [GO:0043524],
negative regulation of blood vessel endothelial cell migration [GO:0043537],
post-translational protein modification [GO:0043687],
reverse cholesterol transport [GO:0043691],
cellular protein metabolic process [GO:0044267],
positive regulation by host of viral process [GO:0044794],
regulation of innate immune response [GO:0045088],
negative regulation of cholesterol biosynthetic process [GO:0045541],
positive regulation of endocytosis [GO:0045807],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of lipid biosynthetic process [GO:0046889],
intracellular transport [GO:0046907],
regulation of neuronal synaptic plasticity [GO:0048168],
artery morphogenesis [GO:0048844],
negative regulation of protein secretion [GO:0050709],
negative regulation of inflammatory response [GO:0050728],
positive regulation of nitric-oxide synthase activity [GO:0051000],
positive regulation of membrane protein ectodomain proteolysis [GO:0051044],
regulation of protein metabolic process [GO:0051246],
maintenance of location in cell [GO:0051651],
fatty acid homeostasis [GO:0055089],
positive regulation of dendritic spine development [GO:0060999],
regulation of proteasomal protein catabolic process [GO:0061136],
response to caloric restriction [GO:0061771],
triglyceride homeostasis [GO:0070328],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
triglyceride-rich lipoprotein particle clearance [GO:0071830],
intermediate-density lipoprotein particle clearance [GO:0071831],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
regulation of cholesterol metabolic process [GO:0090181],
negative regulation of triglyceride metabolic process [GO:0090209],
AMPA glutamate receptor clustering [GO:0097113],
NMDA glutamate receptor clustering [GO:0097114],
cellular oxidant detoxification [GO:0098869],
regulation of beta-amyloid clearance [GO:1900221],
negative regulation of long-term synaptic potentiation [GO:1900272],
negative regulation of neuron death [GO:1901215],
positive regulation of postsynaptic membrane organization [GO:1901628],
negative regulation of presynaptic membrane organization [GO:1901630],
negative regulation of beta-amyloid formation [GO:1902430],
positive regulation of dendritic spine maintenance [GO:1902952],
positive regulation of phospholipid efflux [GO:1902995],
positive regulation of lipid transport across blood brain barrier [GO:1903002],
regulation of behavioral fear response [GO:2000822],
lipid metabolic process [GO:0006629],
lipid transport [GO:0006869],
response to oxidative stress [GO:0006979],
aging [GO:0007568],
protein localization [GO:0008104],
regulation of gene expression [GO:0010468],
axon regeneration [GO:0031103],
regulation of apoptotic process [GO:0042981],
positive regulation of axon extension [GO:0045773],
regulation of synapse organization [GO:0050807],
lipid homeostasis [GO:0055088],
cardiovascular system development [GO:0072358],
regulation of triglyceride metabolic process [GO:0090207],
regulation of plasma lipoprotein particle levels [GO:0097006],

Molecular Function:
beta-amyloid binding [GO:0001540],
receptor binding [GO:0005102],
structural molecule activity [GO:0005198],
lipid transporter activity [GO:0005319],
protein binding [GO:0005515],
phospholipid binding [GO:0005543],
heparin binding [GO:0008201],
lipid binding [GO:0008289],
cholesterol binding [GO:0015485],
antioxidant activity [GO:0016209],
cholesterol transporter activity [GO:0017127],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
heparan sulfate proteoglycan binding [GO:0043395],
macromolecular complex binding [GO:0044877],
metal chelating activity [GO:0046911],
protein dimerization activity [GO:0046983],
tau protein binding [GO:0048156],
low-density lipoprotein particle receptor binding [GO:0050750],
phosphatidylcholine-sterol O-acyltransferase activator activity [GO:0060228],
very-low-density lipoprotein particle receptor binding [GO:0070326],
lipoprotein particle binding [GO:0071813],
hydroxyapatite binding [GO:0046848],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
early endosome [GO:0005769],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum lumen [GO:0005788],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
membrane [GO:0016020],
dendrite [GO:0030425],
clathrin-coated endocytic vesicle membrane [GO:0030669],
extracellular matrix [GO:0031012],
very-low-density lipoprotein particle [GO:0034361],
low-density lipoprotein particle [GO:0034362],
intermediate-density lipoprotein particle [GO:0034363],
high-density lipoprotein particle [GO:0034364],
discoidal high-density lipoprotein particle [GO:0034365],
chylomicron [GO:0042627],
neuronal cell body [GO:0043025],
synaptic cleft [GO:0043083],
extracellular exosome [GO:0070062],
endocytic vesicle lumen [GO:0071682],
blood microparticle [GO:0072562],
glutamatergic synapse [GO:0098978],
extracellular vesicle [GO:1903561],
lipoprotein particle [GO:1990777],
nuclear envelope [GO:0005635],
lysosome [GO:0005764],
endosome [GO:0005768],
late endosome [GO:0005770],
microtubule [GO:0005874],
cell surface [GO:0009986],
extrinsic component of external side of plasma membrane [GO:0031232],
synapse [GO:0045202],