APLN

apelin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29117554 C85 Mouse NO
30002688 HUVEC Human NO

GO terms:

Biological Process:
angiogenesis [GO:0001525],
regulation of the force of heart contraction [GO:0002026],
immune response [GO:0006955],
signal transduction [GO:0007165],
G-protein coupled receptor signaling pathway [GO:0007186],
gastrulation [GO:0007369],
lactation [GO:0007595],
regulation of receptor activity [GO:0010469],
negative regulation of gene expression [GO:0010629],
positive regulation of heat generation [GO:0031652],
negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037],
positive regulation of phosphorylation [GO:0042327],
drinking behavior [GO:0042756],
regulation of respiratory gaseous exchange [GO:0043576],
negative regulation of blood pressure [GO:0045776],
positive regulation of heart contraction [GO:0045823],
negative regulation of vasoconstriction [GO:0045906],
positive regulation of corticotropin secretion [GO:0051461],
positive regulation of corticotropin-releasing hormone secretion [GO:0051466],
apelin receptor signaling pathway [GO:0060183],
coronary vasculature development [GO:0060976],
positive regulation of pri-miRNA transcription from RNA polymerase II promoter [GO:1902895],
positive regulation of G-protein coupled receptor internalization [GO:1904022],
negative regulation of vascular smooth muscle cell proliferation [GO:1904706],
positive regulation of vascular endothelial cell proliferation [GO:1905564],
multicellular organism development [GO:0007275],
feeding behavior [GO:0007631],
positive regulation of cell proliferation [GO:0008284],
regulation of body fluid levels [GO:0050878],

Molecular Function:
receptor binding [GO:0005102],
hormone activity [GO:0005179],
apelin receptor binding [GO:0031704],
protein homodimerization activity [GO:0042803],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
perinuclear region of cytoplasm [GO:0048471],